Intranasal immunization with the cholera toxin B subunit-pneumococcal surface antigen a fusion protein induces protection against colonization with Streptococcus pneumoniae and has negligible impact on the nasopharyngeal and oral microbiota of mice
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2006-08
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One of the candidate proteins for a mucosal vaccine antigen against Streptococcus pneumoniae is PsaA
(pneumococcal surface antigen A). Vaccines targeting mucosal immunity may raise concerns as to possible
alterations in the normal microbiota, especially in the case of PsaA, which was shown to have homologs with
elevated sequence identity in other viridans group streptococci. In this work, we demonstrate that intranasal
immunization with a cholera toxin B subunit-PsaA fusion protein is able to protect mice against colonization
with S. pneumoniae but does not significantly alter the natural oral or nasopharyngeal microbiota of mice.
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PIMENTA, F. C. et. al. Intranasal immunization with the cholera toxin B subunit-pneumococcal surface antigen a fusion protein induces protection against colonization with Streptococcus pneumoniae and has negligible impact on the nasopharyngeal and oral microbiota of mice. Infection and Immunity, Washington, v. 74, n. 8, p. 4939-4944, 2006.