Prevalence of hepatitis A virus infection in Goiânia, Goiás, Brazil, by molecular and serological procedures, 1995-2002
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Data
2006-06
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Resumo
In this study, a total of 865 serum samples were collected between 1995 and 2002 from individuals living in
Goiânia, Central Brazil, and clinically suspected of hepatitis. After exclusion of 162 samples which were positive for
hepatitis B virus or hepatitis C virus, 703 samples were tested for anti-hepatitis A virus (anti-HAV) IgM antibodies
by enzyme immunoassay. In addition, 588 of these samples and 22 fecal samples were analyzed by reverse transcrip-
tion-nested PCR for HAV RNA detection, with positivity indices of 13.1% (77/588) and 54.5% (12/22), respectively.
A similar index of viral RNA detection in anti-HAV-IgM positive or negative samples was observed in serum samples.
HAV infection is a public health problem worldwide and this study underscores the extent of HAV circulation in our
region.
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Hepatitis A virus, Goiânia, Prevalence, Anti-HAV-IgM, Viral RNA, Brazil
Citação
FIACCADORI, Fabíola Souza; SOARES, Célia Maria de Almeida; BORGES, Ana Maria Tavares CARDOSO, Divina das Dores de Paula. Prevalence of hepatitis A virus infection in Goiânia, Goiás, Brazil, by molecular and serological procedures, 1995-2002. Memórias do Instituto Oswaldo Cruz, Rio de Janeiro, Brasil, v. 101, n. 4, p. 423-426, June 2006.