Use este identificador para citar ou linkar para este item: http://repositorio.bc.ufg.br/handle/ri/15580
Tipo do documento: Artigo
Título: Genotoxicity and cytotoxicity evaluation of the neolignan analogue 2-(4-nitrophenoxy)-1phenylethanone and its protective effect against DNA damage
Autor: Hanusch, Alex Lucas
Oliveira, Guilherme Roberto de
Sabóia-Morais, Simone Maria Teixeira de
Machado, Rafael Cosme
Anjos, Murilo Machado dos
Lee, Chen Chen
Abstract: Neolignans are secondary metabolites found in various groups of Angiosperms. They belong to a class of natural compounds with great diversity of chemical structures and pharmacological activities. These compounds are formed by linking two phenylpropanoid units. Several compounds that have ability to prevent genetic damage have been isolated from plants, and can be used to prevent or delay the development of tumor cells. Genetic toxicology evaluation is widely used in risk assessment of new drugs in preclinical screening tests. In this study, we evaluated the genotoxicity and cytotoxicity of the neolignan analogue 2-(4- nitrophenoxy)-1-phenylethanone (4NF) and its protective effect against DNA damage using the mouse bone marrow micronucleus test and the comet assay in mouse peripheral blood. Our results showed that this neolignan analogue had no genotoxic activity and was able to reduce induced damage both in mouse bone marrow and peripheral blood. Although the neolignan analogue 4NF was cytotoxic, it reduced cyclophosphamide-induced cytotoxicity. In conclusion, it showed no genotoxic action, but exhibited cytotoxic, antigenotoxic, and anticytotoxic activities.
País: Estados unidos
Unidade acadêmica: Instituto de Química - IQ (RG)
Citação: HANUSCH, Alex lucas et al. Genotoxicity and cytotoxicity evaluation of the neolignan analogue 2-(4-nitrophenoxy)-1phenylethanone and its protective effect against DNA damage. Plos One, San Francisco, v. 10, n. 11, e0142284, Nov. 2015.
Tipo de acesso: Acesso Aberto
Identificador do documento: 10.1371/journal.pone.0142284
Identificador do documento: 10.1371/journal.pone.0142284
URI: http://repositorio.bc.ufg.br/handle/ri/15580
Data de publicação: Nov-2015
Aparece nas coleções:IQ - Artigos publicados em periódicos

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