Use este identificador para citar ou linkar para este item: http://repositorio.bc.ufg.br/handle/ri/15584
Tipo do documento: Artigo
Título: Lagochilascaris minor: susceptibility and resistance to experimental infection in mice is independent of H-2a haplotype and correlates with the immune response in immunized animals
Autor: Ferreira, Mônica Spadafora
Fernandes, Luciana Caetano
Pfrimer, Irmtraut Araci Hoffmann
Pichiteli, Cássia Regina
Tambourgi, Denise Vilarinho
Lino Junior, Ruy de Souza
Carvalhaes, Mara Silvia
Abstract: Recently, we demonstrated that C57BL/6 mice are more susceptible to experimental lagochilascariosis than BALB/c mice. To investigate the pattern of infection and the role of the genetic background on susceptibility to infection, we studied experimental lagochilascariosis in H-2 a identical B10.A and A/J mice. Infected B10.A mice had a lower survival ratio and more severe lesions in the lungs than did A/J mice. Splenocytes of A/J mice immunized with the crude extract of the parasite showed increased proliferation and produced a higher level of interleukin 10 and interferon-γ in the presence of CE or concanavalin A when compared to B10.A mice. This suggests that resistance of A/J mice may be due to less severe lesions in lungs and other organs and a better immune response to parasite antigens. This paper provides evidence that major histocompatibility complex haplotype does not influence the survival to experimental infection with L. minor.
País: Gra-bretanha
Unidade acadêmica: Instituto de Patologia Tropical e Saúde Pública - IPTSP (RG)
Citação: SPADAFORA-FERREIRA, Mônica; FERNANDES, Luciana Caetano; PFRIMER, Irmtraut Araci Hoffman; PICHITELI, Cássia Regina; TAMBOURGI, Denise Vilarinho; LINO-JUNIOR, Ruy de Souza; CARVALHAES, Mara Silvia. Lagochilascaris minor: susceptibility and resistance to experimental infection in mice is independent of H-2a haplotype and correlates with the immune response in immunized animals. Journal of Parasitology Research, London, v. 2010, p. 1-9, 2010.
Tipo de acesso: Acesso Aberto
Identificador do documento: 10.1155/2010/610457
Identificador do documento: 10.1155/2010/610457
URI: http://repositorio.bc.ufg.br/handle/ri/15584
Data de publicação: 2010
Aparece nas coleções:IPTSP - Artigos publicados em periódicos

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