Use este identificador para citar ou linkar para este item: http://repositorio.bc.ufg.br/handle/ri/15693
Tipo do documento: Artigo
Título: Excitatory amino acid receptors mediate asymmetry and lateralization in the descending cardiovascular pathways from the dorsomedial hypothalamus
Autor: Custódio, Carlos Henrique Xavier
Ianzer, Danielle Alves
Lima, Augusto Martins
Marins, Fernanda Ribeiro
Pedrino, Gustavo Rodrigues
Vaz, Gisele Cristiane
Menezes, Gustavo Batista de
Nalivaiko, Eugene
Fontes, Marco Antônio Peliky
Abstract: The dorsomedial hypothalamus (DMH) and lateral/dorsolateral periaqueductal gray (PAG) are anatomically and functionally connected. Both the DMH and PAG depend on glutamatergic inputs for activation. We recently reported that removal of GABA-ergic tone in the unilateral DMH produces: asymmetry, that is, a right- (R-) sided predominance in cardiac chronotropism, and lateralization, that is, a greater increase in ipsilateral renal sympathetic activity (RSNA). In the current study, we investigated whether excitatory amino acid (EAA) receptors in the DMH–PAG pathway contribute to the functional interhemispheric difference. In urethane (1.2 to 1.4 g/kg, i.p.) anesthetized rats, we observed that: (i) nanoinjections of N-methyl D-aspartate (NMDA 100 pmol/100 nl) into the unilateral DMH produced the same right-sided predominance in the control of cardiac chronotropy, (ii) nanoinjections of NMDA into the ipsilateral DMH or PAG evoked lateralized RSNA responses, and (iii) blockade of EAA receptors in the unilateral DMH attenuated the cardiovascular responses evoked by injection of NMDA into either the R- or left- (L-) PAG. In awake rats, nanoinjection of kynurenic acid (1 nmol/100 nL) into the L-DMH or R- or L-PAG attenuated the tachycardia evoked by air stress. However, the magnitude of stress-evoked tachycardia was smallest when the EAA receptors of the R-DMH were blocked. We conclude that EAA receptors contribute to the right-sided predominance in cardiac chronotropism. This interhemispheric difference that involves EAA receptors was observed in the DMH but not in the PAG.
País: Estados unidos
Unidade acadêmica: Instituto de Ciências Biológicas - ICB (RG)
Citação: XAVIER, Carlos Henrique; IANZER, Danielle; LIMA, Augusto Martins; MARINS, Fernanda Ribeiro; PEDRINO, Gustavo Rodrigues; VAZ, Gisele; MENEZES, Gustavo Batista; NALIVAIKO, Eugene; FONTES, Marco Antônio Peliky. Excitatory amino acid receptors mediate asymmetry and lateralization in the descending cardiovascular pathways from the dorsomedial hypothalamus. PLoS One, San Francisco, v. 9, e112412, Nov. 2014.
Tipo de acesso: Acesso Aberto
Identificador do documento: 10.1371/journal.pone.0112412
Identificador do documento: 10.1371/journal.pone.0112412
URI: http://repositorio.bc.ufg.br/handle/ri/15693
Data de publicação: Nov-2014
Aparece nas coleções:ICB - Artigos publicados em periódicos

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