Siolmatra brasiliensis (Cogn.) Baill., Cucurbitaceae, acute toxicity in mice
Carregando...
Data
2010-12
Título da Revista
ISSN da Revista
Título de Volume
Editor
Resumo
Siolmatra brasiliensis (Cogn.) Baill., Cucurbitaceae, commonly known as
“pluméria” or “taiuiá”, is widely used in different ways in Brazilian popular medicine to treat
several diseases. Acute toxicity of Siolmatra brasiliensis crude ethanolic extract (CEE) was
investigated in mice. No mortality or signs of CEE toxicity were observed at the doses of 10
and 100 mg/kg bw, but the administration of 1000 and 2000 mg/kg bw caused several adverse
behavioral effects and mortality. Macroscopic inspection of the organs showed morphologic
alterations in the heart of animals treated with doses of 1000 and 2000 mg/kg bw. According
to our results, S. brasiliensis CEE has an LD50 of 1000 mg/kg bw. We conclude that S.
brasiliensis CEE was safe at the doses of 10 and 100 mg/kg bw and presented toxicity at the
doses of 1000 and 2000 mg/kg bw.
Descrição
Palavras-chave
Siolmatra brasiliensis, Camundongo, Toxicidade, Cucurbitaceae, Siolmatra brasiliensis, Cucurbitaceae, Toxicity, Mice
Citação
LIMA, Aliny P.; BARBOSA, Carlos E. S.; PEREIRA, Flávia C.; VILANOVA-COSTA, Cesar A. S. T.; RIBEIRO, Alessandra S. B. B.; SILVA, Hugo D.; AZEVEDO, Neucirio R.; GOMES-KLEIN, Vera L.; SILVEIRA-LACERDA, Elisângela P. Siolmatra brasiliensis (Cogn.) Baill., Cucurbitaceae, acute toxicity in mice. Revista Brasileira de Farmacognosia, Curitiba, v. 20, n. 6, p. 917-921, Dec. 2010.