Use este identificador para citar ou linkar para este item: http://repositorio.bc.ufg.br/handle/ri/15862
Tipo do documento: Artigo
Título: Evaluation of analgesic and anti-inflammatory activities of Hydrocotyle umbellata L., Araliaceae (acariçoba) in mice
Autor: Florentino, Iziara Ferreira
Nascimento, Marcus Vinicius Mariano
Carvalho, Pablinny Moreira Galdino de
Brito, Adriane Ferreira de
Rocha, Fabio Fagundes da
Tonussi, Carlos Rogerio
Lima, Thereza Christina Monteiro de
Paula, José Realino de
Costa, Elson Alves
Abstract: The Hydrocotyle umbellata L. is a specimen of the Araliaceae family popularly known as acariçoba. Its indications in folk medicine include treatment of skin ulcers, and rheumatism. The aim of this study was to evaluate the antinociceptive and anti-inflammatory activities of the ethanolic extract from acariçoba’s underground parts (EEA). EEA reduced the nociceptive response of the animals as evaluated in the acetic acid-induced writhing test and in both phases of formalin test. EEA also presented a supraspinal analgesic activity by increasing the pain latency in the hot plate test. Moreover, EEA reduced the leukocytes migration and plasma extravasation to pleural cavity in the carrageenan-induced pleurisy, besides reducing the edema induced by carrageenan until the second hour and also the edema induced by dextran. In conclusion our results showed that EEA of H. umbellata L. presents analgesic and anti-inflammatory activities, and that a blockade of activity or reduction in the release of different mediators, such as histamine and serotonin, could be involved in these pharmacologic effects.
Palavras-chave: Acariçoba
Hydrocotyle umbellata L.
Anti-inflammatory
Biomedical sciences
Antinociceptive
País: Brasil
Unidade acadêmica: Instituto de Ciências Biológicas - ICB (RG)
Citação: FLORENTINO, Iziara F. et al. Evaluation of analgesic and anti-inflammatory activities of Hydrocotyle umbellata L., Araliaceae (acariçoba) in mice. Anais da Academia Brasileira de Ciências, Rio de Janeiro, v. 85, n. 3, p. 987-997, Sept. 2013.
Tipo de acesso: Acesso Aberto
Identificador do documento: 10.1590/S0001-37652013000300011
Identificador do documento: 10.1590/S0001-37652013000300011
URI: http://repositorio.bc.ufg.br/handle/ri/15862
Data de publicação: Set-2013
Aparece nas coleções:ICB - Artigos publicados em periódicos

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