Use este identificador para citar ou linkar para este item: http://repositorio.bc.ufg.br/handle/ri/16052
Tipo do documento: Artigo
Título: Randomized, double-blind clinical trial to assess the acute diuretic effect of Equisetum arvense (Field horsetail) in healthy volunteers
Autor: Carneiro, Danilo Maciel
Freire, Ramias Calixto
Honório, Tereza Cristina de Deus
Zoghaib, Iury Valentim Jorge
Cardoso, Fabiana Fernandes de Santana e Silva
Tresvenzol, Leonice Manrique Faustino
Paula, José Realino de
Sousa, Ana Luiza Lima
Jardim, Paulo César Brandão Veiga
Cunha, Luiz Carlos da
Abstract: In this double-blind, randomized clinical trial, 36 healthy male volunteers were randomly distributed into three groups (𝑛 = 12) that underwent a three-step treatment. For four consecutive days, we alternately administered a standardized dried extract of Equisetum arvense (EADE, 900mg/day), placebo (corn starch, 900mg/day), or hydrochlorothiazide (25mg/day), separated by a 10-day washout period. Each volunteer served as his own control, and the groups’ results were compared. We repeated the same evaluation after each stage of treatment to evaluate the safety of the drug.The diuretic effect of EADE was assessed by monitoring the volunteers’ water balance over a 24 h period. The E. arvense extract produced a diuretic effect that was stronger than that of the negative control and was equivalent to that of hydrochlorothiazide without causing significant changes in the elimination of electrolytes. There was no significant increase in the urinary elimination of catabolites. Rare minor adverse events were reported. The clinical examinations and laboratory tests showed no changes before or after the experiment, suggesting that the drug is safe for acute use. Further research is needed to better clarify the mechanism of diuretic action and the other possible pharmacological actions of this phytomedicine.
País: Gra-bretanha
Unidade acadêmica: Faculdade de Enfermagem - FEN (RG)
Citação: CARNEIRO, Danilo Maciel et al. Randomized, double-blind clinical trial to assess the acute diuretic effect of Equisetum arvense (Field horsetail) in healthy volunteers. Evidence-Based Complementary and Alternative Medicine, London, v. 2014, e760683, 2014.
Tipo de acesso: Acesso Aberto
Identificador do documento: 10.1155/2014/760683
Identificador do documento: 10.1155/2014/760683
URI: http://repositorio.bc.ufg.br/handle/ri/16052
Data de publicação: 2014
Aparece nas coleções:FEN - Artigos publicados em periódicos

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