Use este identificador para citar ou linkar para este item: http://repositorio.bc.ufg.br/handle/ri/16057
Tipo do documento: Artigo
Título: Antinociceptive and anti-inflammatory activities of the ethanolic extract from Synadenium umbellatum pax. (euphorbiaceae) leaves and its fractions
Autor: Oliveira, Rodrigo Borges de
Nascimento, Marcus Vinícius Mariano
Carvalho, Adryano Augustto Valladão de
Valadares, Marize Campos
Paula, José Realino de
Costa, Elson Alves
Cunha, Luiz Carlos da
Abstract: Synadenium umbellatum Pax., popularly known in Brazil as “cola-nota,” “avelós,” “cancerola,” and “milagrosa”, is a plant species used in folk medicine for the treatment of in�ammation, pain, and several diseases. is study aimed to investigate the antinociceptive and anti-in�ammatory activities of the ethanolic extract from Synadenium umbellatum Pax. leaves (EES) and its hexane (HF), chloroform (CF), and methanol/water (MF) fractions using the acetic acid-induced abdominal writhing test, formalin-induced paw licking test, tail �ick test, croton oil-induced ear edema test, and carrageenan-induced peritonitis test. EES and MF reduced the number of acetic acid-induced abdominal writhes, while CF and HF did not. EES effect on acetic acid-induced abdominal writhing was reversed with a pretreatment with naloxone. EES reduced licking time in both phases of the formalin-induced paw licking test, but did not prolong the latency in the tail �ick test. ese results show that EES presented antinociceptive activity, probably involving the opioid system, anti-in�ammatory activity in the croton oil-induced ear edema test, and leukocyte migration into the intraperitoneal cavity. MF also presented anti-in�ammatory activity in the croton oil-induced ear edema test. In conclusion, EES and MF have antinociceptive activity involving the opioid system and anti-in�ammatory activity.
País: Gra-bretanha
Unidade acadêmica: Faculdade de Farmácia - FF (RG)
Citação: BORGES, Rodrigo et al. Antinociceptive and anti-inflammatory activities of the ethanolic extract from Synadenium umbellatum pax. (euphorbiaceae) leaves and its fractions. Evidence-Based Complementary and Alternative Medicine, London, v. 2013, p. 1-9, 2013.
Tipo de acesso: Acesso Aberto
Identificador do documento: 10.1155/2013/715650
Identificador do documento: 10.1155/2013/715650
URI: http://repositorio.bc.ufg.br/handle/ri/16057
Data de publicação: 2013
Aparece nas coleções:ICB - Artigos publicados em periódicos

Arquivos associados a este item:
Arquivo Descrição TamanhoFormato 
Artigo - Rodrigo Borges de Oliveira - 2013.pdf1,46 MBAdobe PDFThumbnail
Baixar/Abrir


Este item está licenciada sob uma Licença Creative Commons Creative Commons