Antinociceptive and anti-inflammatory activities of the ethanolic extract from Synadenium umbellatum pax. (euphorbiaceae) leaves and its fractions
Carregando...
Data
2013
Título da Revista
ISSN da Revista
Título de Volume
Editor
Resumo
Synadenium umbellatum Pax., popularly known in Brazil as “cola-nota,” “avelós,” “cancerola,” and “milagrosa”, is a plant species used
in folk medicine for the treatment of in�ammation, pain, and several diseases. is study aimed to investigate the antinociceptive
and anti-in�ammatory activities of the ethanolic extract from Synadenium umbellatum Pax. leaves (EES) and its hexane (HF),
chloroform (CF), and methanol/water (MF) fractions using the acetic acid-induced abdominal writhing test, formalin-induced
paw licking test, tail �ick test, croton oil-induced ear edema test, and carrageenan-induced peritonitis test. EES and MF reduced
the number of acetic acid-induced abdominal writhes, while CF and HF did not. EES effect on acetic acid-induced abdominal
writhing was reversed with a pretreatment with naloxone. EES reduced licking time in both phases of the formalin-induced paw
licking test, but did not prolong the latency in the tail �ick test. ese results show that EES presented antinociceptive activity,
probably involving the opioid system, anti-in�ammatory activity in the croton oil-induced ear edema test, and leukocyte migration
into the intraperitoneal cavity. MF also presented anti-in�ammatory activity in the croton oil-induced ear edema test. In conclusion,
EES and MF have antinociceptive activity involving the opioid system and anti-in�ammatory activity.
Descrição
Palavras-chave
Citação
BORGES, Rodrigo et al. Antinociceptive and anti-inflammatory activities of the ethanolic extract from Synadenium umbellatum pax. (euphorbiaceae) leaves and its fractions. Evidence-Based Complementary and Alternative Medicine, London, v. 2013, p. 1-9, 2013.