Use este identificador para citar ou linkar para este item: http://repositorio.bc.ufg.br/handle/ri/16814
Tipo do documento: Artigo
Título: New limonoids from hortia oreadica and unexpected coumarin from h. superba using chromatography over cleaning sephadex with sodium hypochlorite
Autor: Severino, Vanessa Gisele Pasqualotto
Freitas, Sâmya Danielle Lima de
Braga, Patrícia Aparecida de Campos
Forim, Moacir Rossi
Silva, Maria Fatima das Gracas Fernandes da
Fernandes, Joao Batista
Vieira, Paulo Cezar
Venâncio, Tiago
Abstract: Previous investigations of H. oreadica reported the presence of a wide spectrum of complex limonoids and dihydrocinnamic acids. Our interest in the Rutaceae motivated a reinvestigation of H. oreadica, H. brasiliana and H. superba searching for other secondary metabolites present in substantial amounts for taxonomic analysis. In a continuation of the investigation of the H. oreadica, three new limonoids have now been isolated 9α-hydroxyhortiolide A, 11β-hydroxyhortiolide C and 1(S*)-acetoxy-7(R*)-hydroxy-7- deoxoinchangin. All the isolated compounds from the Hortia species reinforce its position in the Rutaceae. With regard to limonoids the genus produces highly specialized compounds, whose structural variations do not occur in any other member of the Rutaceae, thus, it is evident from limonoid data that Hortia takes an isolated position within the family. In addition, H. superba afforded the unexpected coumarin 5-chloro-8-methoxy-psoralen, which may not be a genuine natural product. Solid-state cross-polarisation/magic-anglespinning 13C nuclear magnetic resonance, X-Ray fluorescence and Field-emission gun scanning electron microscopy experiments show that the Sephadex LH-20 was modified after treatment with NaOCl, suggesting that when xanthotoxin (8-methoxy-psoralen) was extracted from cleaning of the gel column, chlorination of the aromatic system occurred.
Palavras-chave: Hortia oreadica
H. brasiliana
H. superba
Rutaceae
Limonoids
Alkaloids
Coumarins
Dihydrocinnamic acids
Sephadex LH-20
Chlorination
País: Suica
Unidade acadêmica: Instituto de Química - IQ (RG)
Citação: SEVERINO, Vanessa G. P. et al. New limonoids from hortia oreadica and unexpected coumarin from h. superba using chromatography over cleaning sephadex with sodium hypochlorite. Molecules, Basel, v. 19, p. 12031-12047, Aug. 2014.
Tipo de acesso: Acesso Aberto
Identificador do documento: 10.3390/molecules190812031
Identificador do documento: 10.3390/molecules190812031
URI: http://repositorio.bc.ufg.br/handle/ri/16814
Data de publicação: Ago-2014
Aparece nas coleções:IQ - Artigos publicados em periódicos

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