Use este identificador para citar ou linkar para este item: http://repositorio.bc.ufg.br/handle/ri/16894
Tipo do documento: Artigo
Título: Seroreactivity to new Mycobacterium leprae protein antigens in different leprosy-endemic regions in Brazil
Autor: Hungria, Emerith Mayra
Oliveira, Regiane Morillas de
Souza, Ana Lúcia Osório Maroclo de
Costa, Maurício Barcelos
Souza, Vânia Nieto Brito de
Silva, Eliane Aparecida
Moreno, Fátima Regina Vilani
Nogueira, Maria Esther Salles
Costa, Maria Renata Sales Nogueira
Silva, Sônia Maria Usó Ruiz
Bührer-Sékula, Samira
Reed, Steven G.
Duthie, Malcolm S.
Stefani, Mariane Martins de Araújo
Abstract: New Mycobacterium leprae protein antigens can contribute to improved serologic tests for leprosy diagno-sis/classification and multidrug therapy (MDT) monitoring. This study describes seroreactivity to M. leprae pro-teins among participants from three highly endemic leprosy areas in Brazil: central-western Goiânia/Goiás (GO) (n = 225), Rondonópolis/Mato Grosso (MT) (n = 764) and northern Prata Village/Pará (PA) (n = 93). ELISA was performed to detect IgG to proteins (92f, 46f, leprosy IDRI diagnostic-1, ML0405, ML1213) and IgM to phenolic gly-colipid-I (PGL-I). Multibacillary (MB) leprosy had positive rates for PGL-I that were similar to those for proteins; however, some anti-PGL-I-negative subjects were positive for proteins, suggesting that adding protein antigen to PGL-I can enhance the sensitivity of MB leprosy detection. In MT, different degrees of seroreactivity were observed and ranked for MB, former patients after MDT, paucibacillary (PB) leprosy, household contact (HHC) and endemic control (EC) groups. The seroreactivity of PB patients was low in GO and MT. HHCs from different endemic sites had similar IgG antibody responses to proteins. 46f and 92f were not recognised by most tuberculosis patients, ECs or HHCs within GO, an area with high BCG vaccination coverage. Low positivity in EC and HHC was observed in PA and MT. Our results provide evidence for the development of an improved serologic test that could be widely applicable for MB leprosy testing in Brazil.
Palavras-chave: Serology
Leprosy
Diagnosis
País: Brasil
Unidade acadêmica: Instituto de Patologia Tropical e Saúde Pública - IPTSP (RG)
Citação: HUNGRIA, Emerith Mayra et al. Seroreactivity to new Mycobacterium leprae protein antigens in different leprosy-endemic regions in Brazil. Memórias do Instituto Oswaldo Cruz, Rio de Janeiro, v. 107, p. 104-111, 2012.
Tipo de acesso: Acesso Aberto
Identificador do documento: 10.1590/S0074-02762012000900017
Identificador do documento: 10.1590/S0074-02762012000900017
URI: http://repositorio.bc.ufg.br/handle/ri/16894
Data de publicação: 2012
Aparece nas coleções:IPTSP - Artigos publicados em periódicos

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