Use este identificador para citar ou linkar para este item: http://repositorio.bc.ufg.br/handle/ri/18103
Tipo do documento: Artigo
Título: Preparation of pellets containing Pothomorphe umbellata extracts by extrusion-spheronization: improvement of 4-nerolidylcatechol photostability
Autor: Araújo Júnior, César Aparício de
Costa, Fernanda S. de Oliveira
Taveira, Stephânia Fleury
Marreto, Ricardo Neves
Valadares, Marize Campos
Lima, Eliana M.
Abstract: Pothomorphe umbellata (L.) Miq., Piperaceae, has been extensively used in Brazilian folk medicine and it is well known for its strong antioxidant properties. However, its main active constituent, 4-nerolydilcatechol (4-NC), is sensitive to ultraviolet and visible light, which can limit the use of intermediate and final herbal preparations of this species. In the present work, coated multiparticulate solid dosage forms of P. umbellata were obtained with the purpose of increasing the stability of 4-NC. P. umbellata extract was used as a wetting liquid for the preparation of pellets by extrusion-spheronization. Pellets were coated in a fluidized bed by three different polymers (hydroxypropylmethylcellulose (HPMC), polyvynilpirrolidone K-30 (PVP-K30), and polyvinyl alcohol-polyethylene glycol graft-copolymer (PVA- PEG)). 4-NC photostability was evaluated by an accelerated photostability protocol. Pellets showed a narrow size distribution and low friability. 4-NC photodegradation followed a second order degradation kinetics with similar k values for the percolate, uncoated pellets and HPMC coated pellets. Photoprotection was higher in pellets coated with PVP-K30 and PVA-PEG. PVA-PEG coated pellets with 6 and 9% weight gain resulted in a final concentration of 4-NC approximately cinco times higher than uncoated pellets or liquid extracts, suggesting the potential of this formulation as a multiparticulate solid dosage form for P. umbellata extracts.
Palavras-chave: Extrusion-spheronization
Film coating
Herbal extracts
Multiparticulate solid dosage forms
Nerolidylcatechol
Photostability
País: Brasil
Unidade acadêmica: Faculdade de Farmácia - FF (RG)
Citação: Araújo-Júnior, César Aparício de et al. Preparation of pellets containing Photomorphe umbellata extracts by extrusion-spheronization: improvement of 4-nerolidylcathecol photostability. Revista Brasileira de Farmacognosia, Curtiba, v. 23, n. 1, p. 169-174, Jan./Feb. 2013.
Tipo de acesso: Acesso Aberto
URI: http://repositorio.bc.ufg.br/handle/ri/18103
Data de publicação: Fev-2013
Aparece nas coleções:FM - Artigos publicados em periódicos

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