Use este identificador para citar ou linkar para este item: http://repositorio.bc.ufg.br/handle/ri/19097
Tipo do documento: Artigo
Título: Expression of MMP-2, MMP-9, MMP-14, TIMP-1, TIMP-2 in intraepithelial and invasive cervical neoplasia
Autor: Santos, Silvia Helena Rabelo dos
Andrade, Liliana Aparecida Lucci Angelo
Derchain, Sophie
Pinto, Glauce Aparecida
Morais, Sirlei Siani
Latuf Filho, Paulo Latuf
Abstract: Abstract Aim: To evaluate the expression of MMP-2, MMP-9, MMP-14, TIMP-1 and TIMP-2 in Cervical intraepithelial neoplasia grade 3 (CIN 3) and invasive squamous cell carcinoma. Methods and Results: This study comprised three groups: Group 1: 55 cases with CIN 3; Group 2: 30 cases with CIN 3 and invasive carcinoma components; Group 3: 46 cases with invasive carcinoma. Protein expression was investigated in tumor and stromal cells by immunohistochemistry and percentages of immunostained cells were determined. The mean percentage of MMP-14 tumor cells was significantly higher in stromal cells in all groups. TIMP-2 and MMP-9 expression was significantly higher in stromal cells than in tumor cells. TIMP-1 had a significantly higher expression in stromal cells of carcinoma and tumor cells of CIN 3. Stromal cells expression of MMP-2, MMP14, TIMP-1 was increased with the severity of cervical neoplasia. The expression of MMP-2 in stromal cells that was higher in CIN 3 component of Group 2 than in CIN 3 of Group 1. Conclusions: The increase in MMP-2 expression from CIN 3 to invasive cervical cancer reinforces their role in cervical cancer progression. From CIN 3 to invasive cervical carcinoma, TIMP-1 expression increased in stromal cells and decreased in tumor cells.
Palavras-chave: Matrix metalloproteinase
Tissue inhibitor of metalloproteinases
Cervical intraepithelial neoplasia
Uterine cervical neoplasms
Neoplasm invasiveness
Carcinogenesis
País: Belgica
Unidade acadêmica: Instituto de Patologia Tropical e Saude Publica - IPTSP (RG)
Citação: ESTIN, Maria Cristina do Amaral et al. Expression of MMP-2, MMP-9, MMP-14, TIMP-1, TIMP-2 in intraepithelial and invasive cervical neoplasia. Journal of cytology and histology, Brussels, v. 2, nesp, p. 2-5, Jan. 2015.
Tipo de acesso: Acesso Aberto
Identificador do documento: 10.4172/2157-7099.S3-019
Endereço da licença: http://creativecommons.org/licenses/by-nc-nd/3.0/br/
Identificador do documento: 10.4172/2157-7099.S3-019
URI: http://repositorio.bc.ufg.br/handle/ri/19097
Data de publicação: Jan-2015
Aparece nas coleções:IPTSP - Artigos publicados em periódicos

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