Does the sympathetic nervous system contribute to the pathophysiology of metabolic syndrome?
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Data
2015
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Resumo
The metabolic syndrome (MS), formally known as syndrome X, is a clustering of several
risk factors such as obesity, hypertension, insulin resistance, and dislypidemia which
could lead to the development of diabetes and cardiovascular diseases (CVD). The
frequent changes in the definition and diagnostic criteria of MS are indications of the
controversy and the challenges surrounding the understanding of this syndrome among
researchers. Obesity and insulin resistance are leading risk factors of MS. Moreover,
obesity and hypertension are closely associated to the increase and aggravation of
oxidative stress. The recommended treatment of MS frequently involves change of
lifestyles to prevent weight gain. MS is not only an important screening tool for the
identification of individuals at high risk of CVD and diabetes but also an indicator
of suitable treatment. As sympathetic disturbances and oxidative stress are often
associated with obesity and hypertension, the present review summarizes the role of
sympathetic nervous system and oxidative stress in the MS.
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Palavras-chave
Obesity, Central nervous system, Insulin resistance, Hypertension, Cardiovascular diseases
Citação
MOREIRA, Marina Conceição dos Santos et al. Does the sympathetic nervous system contribute to the pathophysiology of metabolic syndrome? Frontiers in Physiology, Lausanne, v. 6, p. e234, 2015.