Use este identificador para citar ou linkar para este item: http://repositorio.bc.ufg.br/handle/ri/19289
Tipo do documento: Artigo
Título: Catecholaminergic neurons in the comissural region of the nucleus of the solitary tract modulate hyperosmolality-induced responses
Autor: Oliveira, André Henrique Freiria de
Blanch, Graziela Torres
Pedrino, Gustavo Rodrigues
Cravo, Sergio Luiz Domingues
Murphy, David
Menani, Jose Vanderlei
Colombari, Débora Simões de Almeida
Abstract: Catecholaminergic neurons in the comissural region of the nucleus of the solitary tract modulate hyperosmolality-induced responses. Am J Physiol Regul Integr Comp Physiol 309: R1082–R1091, 2015. First published September 2, 2015; doi:10.1152/ajpregu.00432.2014.—Noradrenergic A2 neurons of the nucleus of the solitary tract (NTS) have been suggested to con tribute to body fluid homeostasis and cardiovascular regulation. In the present study, we investigated the effects of lesions of A2 neurons of the commissural NTS (cNTS) on the c-Fos expression in neurons of the hypothalamic paraventricular (PVN) and su praoptic (SON) nuclei, arterial pressure, water intake, and urinary excretion in rats with plasma hyperosmolality produced by intra gastric 2 M NaCl (2 ml/rat). Male Holtzman rats (280 –320 g) received an injection of anti-dopamine- -hydroxylase-saporin (12.6 ng/60 nl; cNTS/A2-lesion, n 28) or immunoglobulin G (IgG)-saporin (12.6 ng/60 nl; sham, n 24) into the cNTS. The cNTS/A2 lesions increased the number of neurons expressing c-Fos in the magnocellular PVN in rats treated with hypertonic NaCl (90 13, vs. sham: 47 20; n 4), without changing the number of neurons expressing c-Fos in the parvocellular PVN or in the SON. Contrary to sham rats, intragastric 2 M NaCl also increased arterial pressure in cNTS/A2-lesioned rats (16 3, vs. sham: 2 2 mmHg 60 min after the intragastric load; n 9), an effect blocked by the pretreatment with the vasopressin antagonist Manning compound (0 3 mmHg; n 10). In addition, cNTS/A2 lesions enhanced hyperosmolality-induced water intake (10.5 1.4, vs. sham: 7.7 0.8 ml/60 min; n 8 –10), without changing renal responses to hyperosmolality. The results suggest that inhib itory mechanisms dependent on cNTS/A2 neurons reduce water intake and vasopressin-dependent pressor response to an acute increase in plasma osmolality.
Palavras-chave: c-Fos expression
Osmoreceptor
Blood pressure
Vasopressin
Thirst
País: Estados unidos
Unidade acadêmica: Instituto de Ciências Biológicas - ICB (RG)
Citação: FREIRIA-OLIVEIRA, Andre H. et al. Catecholaminergic neurons in the comissural region of the nucleus of the solitary tract modulate hyperosmolality-induced responses. American Journal of Physiology-Regulatory, Integrative and Comparative Physiology, Rockville, v. 309, n. 9, p. R1082-R1091, 2015.
Tipo de acesso: Acesso Aberto
Identificador do documento: 10.1152/ajpregu.00432.2014
Endereço da licença: http://creativecommons.org/licenses/by-nc-nd/4.0/
Identificador do documento: 10.1152/ajpregu.00432.2014
URI: http://repositorio.bc.ufg.br/handle/ri/19289
Data de publicação: 2015
Aparece nas coleções:ICB - Artigos publicados em periódicos

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