Alcaloides de Psychotria capitata Ruiz & Pav. (Rubiaceae): determinação estrutural e atividade biológica
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2014-10-09
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Universidade Federal de Goiás
Resumo
Regarding that Psychotria species are described as sources of alkaloids, mainly
β-carboline type with potential biological activity, this work focused on the
phytochemical study of Psychotria capitata Ruiz & Pav. (Rubiaceae) leaves with
widely occurrence on Cerrado Biome.
The study of this specie led to the isolation and structural elucidation of the
alkaloids: bufotenine and bufotenine-N-oxide and coumarin iso-scopelletin.
These alkaloids were found mostly in all studied fractions. Furthermore, two
alkaloids were identified in misture: 6-hydroxide-2-methyl-1,2,3,4-tetrahydro-β-
carboline and 7-carboxyl-2-methyl-dihydro-β-carbolinium. Last one is novel
alkaloid which however still in structural elucidation.
Additionally, considering the great bioactive potential of indol alkaloids,
particularly those found in Psychotria species regarding to central nervous
system biological activity, we have submitted fractions and isolated compounds
of P. capitata to in vitro evaluation with monoamineoxidases MAO-A and MAO-B
as bio targets.
These biological essays was realized in collaboration with research group of
FF/UFRGS that develops studies searching for enzymatic inhibitors involved in
neurodegenerative disease such as Parkinson´s disease and Alzheimer. Thus,
search of compounds that interact with cholinesterase (AChE and BCHE) and
monoamineoxidases (MAO-A and MAO-B) enzymes are important to the
comprehension of neurochemical bases of these diseases.
The alkaloidal fractions of P. capitata (10 mg/mL) showed inhibition rates
between 60 and 89 %, which demonstrate the potential of these fractions.
Bufotenine showed selective inhibiton (89 μM) to MAO-A, while bufotenine-Noxide
didn´t showed inhibition to none of the enzymes.
Therefore, this work contributes to the study of the species of Rubiaceae family,
confirming the great potential of this family as source of indol alkaloids with a β-
carboline nucleous, which show biological activity of great interest.
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WAKUI, V. G. Alcaloides de Psychotria capitata Ruiz & Pav. (Rubiaceae): determinação estrutural e atividade biológica. 2014. 91 f. Dissertação (Mestrado em Química) - Universidade Federal de Goiás, Goiânia, 2015.