Avaliação da atividade antifúngica de curcuma longa sobre candida parapsilosis
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Data
2015-09-23
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Editor
Ruy de Souza Lino Junior
Resumo
Among fungal infections that affect human beings, candidiasis has significant relevance. Its
most common etiological agent is Candida albicans, but over the past three decades candidiasis episodes caused by other species, such as Candida parapsilosis, have emerged. The Brazilian
Cerrado has a huge morphological diversity of plants. Curcuma longa, a plant widely found in
this biome, has been studied both for its antibacterial and antifungal activity. The aim of this study
was to evaluate the antifungal activity of C. longa on C. parapsilosis by analyzing the inhibitory
capacity of extracts from different parts of the plant on the fungus. The antifungal activity of
ethanolic extracts from rhizomes and leaves of C. longa was evaluated by the macrodilution
method, determining the minimum inhibitory concentration (MIC), alongside sensitivity testing
performed in plates and by the diffusion disk method. We also evaluated the synergy between
the extracts in combination with traditional antifungal drugs. C. longa has antifungal activity on
the growth of C. parapsilosis with a MIC value obtained from ethanolic extracts of 500 ppm for
rhizomes and leaves. It was possible to observe synergistic activity between the leaf extracts and
amphotericin B and antagonistic activity between rhizome extracts and amphotericin B. It may
be concluded that the leaf and rhizome extracts of C. longa have antifungal activity against C.
parapsilosis in a dose-dependent manner, showing the antifungal potential of the plant
Descrição
v. 44, n. 3, p. 258-270, jul./set. 2015.
Palavras-chave
C. parapsiliosis, Candidíase, C. longa, Plantas medicinais, Inibidor, Cerrado, candidiasis, Inhibitor, Medicinal plants
Citação
PACHECO, Danillo dos Reis; SOARES, Dannúbia Emanuelle Dâmaso; SILVA NETO, Carlos de Melo; SILVA, Gilmar Aires da; PRADO, Renata Silva do. Avaliação da atividade antifúngica de curcuma longa sobre candida parapsilosis. Revista de Patologia Tropical, Goiânia, v. 44, n. 3, p. 258-270, jul./set., 2015. Disponível em: < http://www.revistas.ufg.br/index.php/iptsp/article/view/38022/19145>.