Focus on pneumococcal vaccines and nasopharyngeal carriage
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Data
2010
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Resumo
The vaccination is the only available tool to prevent disease caused by Streptococcus pneumoniae. In this review emphasis
was given on pneumococcal conjugate vaccine (PCV) and S. pneumoniae nasopharyngeal carriage, as nasopharynx colonization
precede invasive disease. To optimize the development of future conjugate vaccines and to evaluate their efficacy, it is
necessary to understand the serogroup specific epidemiology of pneumococci and their associated disease types.
Continuous monitoring of S. pneumoniae serotypes is essential since it has been shown that the incidence of types responsible
for invasive disease can change over time. The extended protection increases the cost effectiveness of PCV and should
clearly encourage its use in poorly resourced countries. However, the accumulated experience also shows that the herd
immunity, due to PCV, is partly offset by replacement of the vaccine serotypes by other, nonvaccine serotypes. Owing to the
general reduced virulence of the latter, this has only had a modest effect on disease, but the possibility of more virulent
nonvaccine serotypes arising cannot be ignored and should be the focus of continued surveillance
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Palavras-chave
Streptococcus pneumoniae, Pneumococcal vaccine, Nasopharyngeal carriage, Vaccines, Streptococcus pneumoniae, Vacina pneumocócica, Portador na nasofaringe, Vacinas
Citação
Rocha, Cristyane G. B. B.; ANDRADE, Ana Lucia S. S.; PIMENTA, Fabiana C. Focus on pneumococcal vaccines and nasopharyngeal carriage. Revista Ciências Médicas e Biológicas, v. 9, n. 1, p. 60-64, 2010.