Aspectos macroscópicos da cardiopatia chagásica crônica no envelhecimento
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Data
2007
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Resumo
Objective: To describe the macroscopic characteristics of chronic Chagas heart disease in autopsied elderly.
Methods: The elderly studied were 60 or older. Twenty of them had chronic Chagas heart disease (CHD) and positive serology for the disease,
and 14 had no heart disease (WHD) nor morphological changes suggestive of it and were serologically negative for Chagas disease.
Results: The CHD elderly had cardiac weight greater than the WHD (385 ± 141.1 vs 306.8 ± 62.1g, respectively; p > 0.05), in addition to
significantly higher heart weight-to-body weight ratio (0.71% [0.5-1.42%] vs 0.59% [0.47-0.91%] p < 0.05). When compared, the CHD elderly
presented lower fibrous thickening and/or atherosclerosis in the ascending aorta, mitral and tricuspid valves, and left and right coronaries than
the WHD elderly. In the aortic and mitral valves, the lesions were significantly less severe (p < 0.05). Left ventricular apical lesion was observed
in 45% of the CHD elderly, and intracardiac thrombosis in the left ventricle was found in 10% of them.
Conclusion: Fibrous thickening and/or atherosclerosis were found to be less severe in the valves and arteries of the CHD elderly. Moreover, heart
weight and intracardiac thrombosis frequency were lower than those detailed in the literature for non-elderly individuals.
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Cardimiopatia chagásica, Envelhecimento, Aterosclerose, Doença de Chagas, Chagas cardimiopathy, Chagas disease, Aging, Atherosclerosis
Citação
OLIVEIRA, Flávia Aparecida de; TEIXEIRA, Vicente de Paula Antunes; LINO JUNIOR, Ruy de Souza; VINAUD, Marina Clare; REIS, Marlene Antônia dos. Aspectos macroscópicos da cardiopatia chagásica crônica no envelhecimento. Arquivos Brasileiros de Cardiologia, São Paulo, v. 88, n. 4, p. 486-490, abr. 2007.