In silico repositioning of new drugs against Schistosoma mansoni

Página do item simplificado
dc.creatorBezerra, José Clecildo Barreto
dc.creatorArantes, Morgana Elias
dc.creatorAndrade, Carolina Horta
dc.creatorSilva, Lourival Almeida
dc.creatorNeves, Bruno Junior
dc.date.accessioned2019-10-23T13:13:51Z
dc.date.available2019-10-23T13:13:51Z
dc.date.issued2018-09
dc.description.abstractSchistosomiasis is a neglected tropical disease caused by parasites of the genus Schistosoma. In Brazil only Schistosoma mansoni causes this disease. The World Health Organization estimated in 2012 approximately 249 million people at risk of acquiring this disease around the world. The main strategy to control this disease is praziquantel treatment of individuals living in endemic areas. The drug praziquantel is used on a large scale in the treatment of schistosomiasis and currently there are reported cases of resistance, indicating the need to discover new drugs. In silico drug repositioning is a time and cost reducing strategy in the search for anti-Schistosoma agents. This work used bioinformatic tools to identify potential schistosomicidal drugs. A list was compiled of S. mansoni potential targets that are part of essential processes in the database TDR and the targets that are part of the tegument were obtained in the scientific literature. The file with S. mansoni targets contained 1,376 targets, and of these only 61 targets associated with 399 drugs had homology with drug targets. After removal of duplicate drugs, drugs found in previous studies and after the analysis of the conservation of the binding site, only 28 S. mansoni targets associated with 102 drugs had 60% or more of the active site conserved. Some of the drugs had activity and are interesting to validate this study such as: artemether, lumefantrine, meloxicam. Among the drugs found 18 drugs were selected to be tested in prospective experimental assays according to the following criteria: low toxicity in vivo, off-patent status, and logP <5.0.pt_BR
dc.description.sponsorshipUFGpt_BR
dc.description.sponsorshipSociedade Brasileira de Parasitologiapt_BR
dc.identifier.citationBEZERRA, José Clecildo Barreto; ARANTES, Morgana Elias; ANDRADE, Carolina Horta; SILVA, Lourival Almeida; NEVES, Bruno Junior. In silico repositioning of new drugs against Schistosoma mansoni. Revista de Patologia Tropical, Goiânia, v. 47, n. 3, p. 159-166, jul./sep. 2018. Disponível em: https://www.revistas.ufg.br/iptsp/article/view/55429/26478.pt_BR
dc.identifier.doi0.5216/rpt.v47i3.55429
dc.identifier.issne- 1980-8178
dc.identifier.urihttp://repositorio.bc.ufg.br/handle/ri/18284
dc.language.isoengpt_BR
dc.publisherRuy de Souza Lino Juniorpt_BR
dc.publisher.countryBrasilpt_BR
dc.publisher.departmentInstituto de Patologia Tropical (IPTSP) - RGpt_BR
dc.publisher.initialsUFGpt_BR
dc.rightsAcesso Abertopt_BR
dc.subjectControlpt_BR
dc.subjectSchistosoma mansonipt_BR
dc.subjectDrug repositioningpt_BR
dc.subjectChemogenomicspt_BR
dc.titleIn silico repositioning of new drugs against Schistosoma mansonipt_BR
dc.typeArtigopt_BR

Arquivos

Pacote Original
Agora exibindo 1 - 1 de 1
Imagem de Miniatura
Nome:
Artigo - José Clecildo Barreto Bezerra - 2018.pdf
Tamanho:
562.77 KB
Formato:
Adobe Portable Document Format
Baixar
Licença do Pacote
Agora exibindo 1 - 1 de 1
Nenhuma Miniatura disponível
Nome:
license.txt
Tamanho:
1.71 KB
Formato:
Item-specific license agreed upon to submission
Descrição:
Baixar

Coleções

IPTSP - Artigos publicados em periódicos