Clinical and laboratory features of HTLV-I asymptomatic carriers and patients with HTLV-I-associated myelopathy/ tropical spastic paraparesis from the Brazilian Amazon

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dc.creatorTakatani, Massanobu
dc.creatorCrispim, Myuki Alfaia Esashika
dc.creatorFraiji, Nelson Abrahim
dc.creatorStefani, Mariane Martins de Araújo
dc.creatorKiesslich, Dagmar
dc.date.accessioned2025-02-17T13:56:22Z
dc.date.available2025-02-17T13:56:22Z
dc.date.issued2017
dc.description.abstractClinical and laboratory parameters including blood and cerebrospinal fluid (CSF) neopterin were investigated in human-T-lymphotropic-virus-type-I associated-myelopathy/tropical spastic-paraparesis-HAM/TSP and in HTLV-I carriers. HAM/TSP (n = 11, 2 males/9 females, median age = 48 years), recently diagnosed HTLV-I carriers (n = 21, 15 females/6 males, median age = 44 years), healthy individuals (n = 20, 10 males/10 females, median age = 34.6 years) from the Brazilian Amazon (Manaus, Amazonas State) were investigated. Neopterin was measured (IBL ELISA Neopterin, Germany) in serum samples of all the participants, in CSF of 9 HAM/TSP patients as well as in 6 carriers. In HAM/TSP patients, CSF cell counts, protein and glucose were measured, the Osame’s motor-disability-score/OMDS was determined, and brain/spinal cord magnetic-resonance-imaging (MRI) was performed. HAM/TSP patients had normal CSF glucose, leukocyte counts; and normal protein levels predominated. Brain MRI showed white-matter lesions in 7 out of 11 HAM/TSP patients. OMDS varied from 2-8: 9 were able to walk, 2 were wheel-chair-users. The median serum neopterin concentration in HAM/TSP patients was 6.6 nmol/ L; min. 2.8- max. 12.5 nmol/ L); was lower in carriers (4.3 nmol/L; min. 2.7- max. 7.2 nmol/ L) as well as in healthy participants (4.7 nmol/ L; min. 2.7- max. 8.0 nmol/ L) (p < 0.05). CSF neopterin concentrations in HAM/TSP patients were higher than in serum samples, and higher compared to carriers (p < 0.05). Carriers had similar serum-CSF neopterin concentrations compared to healthy participants. Variable clinical and laboratory profiles were seen in HAM/TSP patients, however our results support the neopterin measurement as a potential biomarker of disease activity.
dc.identifier.citationTAKATANI, Massanobu et al. Clinical and laboratory features of HTLV-1 asymptomatic carriers and patients with HTLV-1-associated myelopathy/tropical spastic paraparesis from the Brazilian Amazon. Revista do Instituto de Medicina Tropical de São Paulo, São Paulo, v. 59, e5, 2017. DOI: 10.1590/S1678-9946201759005. Disponível em: https://www.scielo.br/j/rimtsp/a/8rmYVBKKRfg4bG4kwQkSmzC/?lang=en. Acesso em: 12 fev. 2025.
dc.identifier.doi10.1590/S1678-9946201759005
dc.identifier.issn0036-4665
dc.identifier.issne- 1678-9946
dc.identifier.urihttp://repositorio.bc.ufg.br//handle/ri/26702
dc.language.isoeng
dc.publisher.countryBrasil
dc.publisher.departmentInstituto de Patologia Tropical e Saúde Pública - IPTSP (RMG)
dc.rightsAcesso Aberto
dc.rights.urihttp://creativecommons.org/licenses/by-nc-nd/4.0/
dc.subjectHAM/TSP patients
dc.subjectHTLV-I carriers
dc.subjectNeopterin
dc.subjectCerebrospinal fluid
dc.titleClinical and laboratory features of HTLV-I asymptomatic carriers and patients with HTLV-I-associated myelopathy/ tropical spastic paraparesis from the Brazilian Amazon
dc.typeArtigo

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