Polymethyl methacrylate (Linnea Safe) causes local inflammatory response after intramuscular implant in BALB/c mice but it is not observed in distant organs
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2016
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Introduction: Among its different therapeutic functions, the use of polymethyl methacrylate (PMMA) for more than a decade has has
stood out in the replacement of the volumes lost with the aging process and filling in wrinkles and creases. It is considered a permanent
biomaterial despite its reliability is widely discussed by health professionals. Objective: To analyze the size of the microspheres in of three
different commercialized types of PMMA, and the inflammatory process generated by the implant, as well as to evaluate possible migration
of the microspheres. Methods: The polymers of the brands Biossimetric®, MetaCrill® and Linnea Safe® were analyzed by scanning
electron microscope (SEM) and had the dispersion and the size of its particles determined. After this analysis, it was decided to implant
in BALB/c mice the polymer of the brand Linnea Safe®, which was the more homogeneous product. The animals submitted to polymer
implantation were euthanized at 3, 7, 15, 30, 60, 90 and 120 days after implantation, allowing the weighing of the implanted paws and
the histopathological analysis of some tissues. Results: It was observed that the implantation of Linnea Safe® PMMA microspheres in mice
triggered an acute inflammatory process 3 to 15 days after the surgical procedure, evolving to chronic non-granulomatous inflammation
with collagen deposition, tissue reorganization after 30 days of PMMA implantation up to 120 days; also, no microspheres were observed
in distant organs. Conclusion: The Linnea Safe® PMMA behaved as a safe and stable biomaterial, once its microspheres were sized to
prevents phagocytosis, and leads to local and controlled inflammation.
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Polymethyl methacrylate, Foreign-body migration, Inflammation, Pathology, Polimetilmetacrilato, Migração de corpo estranho, Inflamação, Patologia
Citação
COSTA, Eduardo Luiz; MILHOMEM, Anália C.; MOURA FILHO, Ronaldo Moisés de; LINO JÚNIOR, Ruy S. Polymethyl methacrylate (Linnea Safe) causes local inflammatory response after intramuscular implant in BALB/c mice but it is not observed in distant organs. Jornal Brasileiro de Patologia e Medicina Laboratorial, Rio de Janeiro, v. 52, n. 6, p. 400-406, 2016. DOI: 10.5935/1676-2444.20160058. Disponível em: https://www.scielo.br/j/jbpml/a/gHYhLZvHyZ8pDWHYKBWFKfK/. Acesso em: 10 abr. 2025.