Interleukin-1 receptor-induced nitric oxide production in the pancreas controls hyperglycemia caused by scorpion envenomation

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dc.creatorReis, Mouzarllem Barros dos
dc.creatorOliveira, Jefferson Elias
dc.creatorPastore, Marcella Roverato
dc.creatorRamos, Simone Gusmão
dc.creatorGardinassi, Luiz Gustavo Araujo
dc.creatorFaccioli, Lúcia Helena
dc.date.accessioned2025-02-04T14:54:00Z
dc.date.available2025-02-04T14:54:00Z
dc.date.issued2020
dc.description.abstractTityus serrulatus causes numerous scorpion envenomation accidents and deaths worldwide. The symptoms vary from local to systemic manifestations, culminating in pulmonary edema and cardiogenic shock. Among these events, transitory hyperglycemia is a severe manifestation that influences pulmonary edema, hemodynamic alterations, and cardiac disturbances. However, the molecular mechanism that leads to increased glucose levels after T. serrulatus envenomation remains unknown. This study aimed to investigate our hypothesis that hyperglycemia due to scorpion envenomation involves inflammatory signaling in the pancreas. The present study showed that T. serrulatus venom induces the production of IL-1α and IL-1β in the pancreas, which signal via IL-1R and provoke nitric oxide (NO) production as well as edema in β-cells in islets. Il1r1-/- mice were protected from transitory hyperglycemia and did not present disturbances in insulin levels in the serum. These results suggest that the pathway driven by IL-1α/IL-1β-IL-1R-NO inhibits insulin release by β-cells, which increases systemic glucose concentration during severe scorpion envenomation. A supportive therapy that inhibits NO production, combined with antiserum, may help to prevent fatal outcomes of scorpion envenomation. Our findings provide novel insights into the design of supportive therapy with NO inhibitors combined with antiscorpion venom serum to overcome fatal outcomes of scorpion envenomation.
dc.identifier.citationREIS, Mouzarllem B. et al. Interleukin-1 receptor-induced nitric oxide production in the pancreas controls hyperglycemia caused by scorpion envenomation. Toxins, Basel, v. 12, n. 3, p. 163, 2020. DOI: 10.3390/toxins12030163. Disponível em: https://www.mdpi.com/2072-6651/12/3/163. Acesso em: 29 jan. 2025.
dc.identifier.doi10.3390/toxins12030163
dc.identifier.issne- 2072-6651
dc.identifier.urihttp://repositorio.bc.ufg.br//handle/ri/26509
dc.language.isoeng
dc.publisher.countrySuica
dc.publisher.departmentInstituto de Patologia Tropical e Saúde Pública - IPTSP (RMG)
dc.rightsAcesso Aberto
dc.rights.urihttp://creativecommons.org/licenses/by-nc-nd/4.0/
dc.subjectScorpion venom
dc.subjectNitric oxide
dc.subjectHyperglycemia
dc.subjectInflammation
dc.subjectPancreas
dc.titleInterleukin-1 receptor-induced nitric oxide production in the pancreas controls hyperglycemia caused by scorpion envenomation
dc.typeArtigo

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