Antifungal activity from Ocimum gratissimum L. towards Cryptococcus neoformans

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dc.creatorMundim, Janine de Aquino Lemos
dc.creatorPassos, Xisto Sena
dc.creatorFernandes, Orionalda de Fátima Lisboa
dc.creatorPaula, José Realino de
dc.creatorFerri, Pedro Henrique
dc.creatorSouza, Lúcia Kioko Hasimoto e
dc.creatorLemos, Aline de Aquino
dc.creatorSilva, Maria do Rosário Rodrigues
dc.date.accessioned2018-08-01T14:09:35Z
dc.date.available2018-08-01T14:09:35Z
dc.date.issued2005-02
dc.description.abstractCryptococcal infection had an increased incidence in last years due to the explosion of acquired immune deficiency syndrome epidemic and by using new and effective immunosuppressive agents. The currently antifungal therapies used such as amphotericin B, fluconazole, and itraconazole have certain limitations due to side effects and emergence of resistant strains. So, a permanent search to find new drugs for cryptococcosis treatment is essen- tial. Ocimum gratissimum, plant known as alfavaca (Labiatae family), has been reported earlier with in vitro activity against some bacteria and dermatophytes. In our work, we study the in vitro activity of the ethanolic crude extract, ethyl acetate, hexane, and chloroformic fractions, essential oil, and eugenol of O. gratissimum using an agar dilution susceptibility method towards 25 isolates of Cryptococcus neoformans. All the extracts of O. gratissimum studied showed activity in vitro towards C. neoformans. Based on the minimal inhibitory concentration values the most significant results were obtained with chloroformic fraction and eugenol. It was observed that chloroformic fraction inhibited 23 isolates (92%) of C. neoformans at a concentration of 62.5 μg/ml and eugenol inhibited 4 isolates (16%) at a concentration of 0.9 μg/ml. This screening may be the basis for the study of O. gratissimum as a possible antifungal agent.pt_BR
dc.identifier.citationLEMOS, Janine de Aquino; PASSOS, Xisto Sena; FERNANDES, Orionalda de Fátima Lisboa; PAULA, José Realino de; FERRI, Pedro Henrique; SOUZA, Lúcia Kioko Hasimoto e; LEMOS, Aline de Aquino; SILVA, Maria do Rosário Rodrigues. Antifungal activity from Ocimum gratissimum L. towards Cryptococcus neoformans. Memórias do Instituto Oswaldo Cruz, Rio de Janeiro, v. 100, n. 1, p. 55-58, Feb. 2005.pt_BR
dc.identifier.doi10.1590/S0074-02762005000100011
dc.identifier.issn0074-0276
dc.identifier.issne- 1678-8060
dc.identifier.urihttp://repositorio.bc.ufg.br/handle/ri/15508
dc.language.isoengpt_BR
dc.publisher.countryBrasilpt_BR
dc.publisher.departmentInstituto de Patologia Tropical e Saúde Pública - IPTSP (RG)pt_BR
dc.rightsAcesso Abertopt_BR
dc.subjectOcimum gratissimumpt_BR
dc.subjectCryptococcus neoformanspt_BR
dc.subjectEssential oilpt_BR
dc.subjectEugenolpt_BR
dc.titleAntifungal activity from Ocimum gratissimum L. towards Cryptococcus neoformanspt_BR
dc.typeArtigopt_BR

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