Atividade larvicida do ácido 3-β-acetoxylabdan-8(17)-13- dien-15-óico isolado da planta medicinal copaifera reticulata (leguminosae) sobre aedes aegypti (diptera, culicidae) evidenciada pelas alterações morfohistológicas
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Data
2014-07-11
Título da Revista
ISSN da Revista
Título de Volume
Editor
Ruy de Souza Lino Junior
Resumo
The main mechanism of control of dengue has been through the fight against Aedes aegypti, the
most competent vector. The fight primarily consists of elimination of its potential breeding sites,
health education and use of synthetic insecticides. These insecticides are effective but are highly
toxic to vertebrates and the environment. With the emergence of resistance of mosquitoes to them,
insecticides of botanical origin are being explored. This study looks at the larvicidal activity of a
solution of a solution of 3-β-acetoxylabdan-8(17)-13-dien-15-óico acid extracted from the medicinal
plant Copaifera reticulata Ducke (Leguminosae) on the 3rd stage larvae of Ae. aegypti. Larvae were
subjected to 9 ppm acid for up to 24 h. Those that reached lethargic state were collected and fixed
in 4% paraformaldhyde in 0.1 M sodium cacodilate buffer, pH 7.2, included in resin and the slides
stained with the hematoxylin-eosin technique and examined by light microscopy. This acid caused the
death of the Ae. aegypti larvae by cell destruction in the midgut, by the high cytoplasmic vacuolation,
cell and nuclear hypertrophy, degeneration of the brush edge, apical vesicular formation with release
of cytoplasmic contents of cells, stratification of the epithelium and folds in the peritrophic matrix.
Descrição
vol. 43, n. 3, p. 375-384, jul./set. 2014.
Palavras-chave
Histologia, Morfologia, Dengue, Febre amarela, Pprodutos naturais, Aedes aegypti, Copaifera reticulata, Natural products, Control
Citação
VALOTTO, Cleyde Ferreira Barreto; CAVASIN, Gláucia; SILVA, Heloisa Helena Garcia da; GERIS, Regina; SILVA, Ionizete Garcia da. Atividade larvicida do ácido 3-β-acetoxylabdan-8(17)-13- dien-15-óico isolado da planta medicinal copaifera reticulata (leguminosae) sobre aedes aegypti (diptera, culicidae) evidenciada pelas alterações morfohistológicas. Revista de Patologia Tropical, Goiânia, GO, vol. 43, n. 3, p. 375-384, jul./set. 2014. Disponível em: < http://www.revistas.ufg.br/index.php/iptsp/article/view/32214>.