Early dystrophin disruption in the pathogenesis of experimental chronic Chagas cardiomyopathy

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dc.creatorPrado, Cibele Maria
dc.creatorCeles, Mara Rúbia Nunes
dc.creatorGiancotti, Lygia Maria Malvestio
dc.creatorPulici, Erica Carolina Campos
dc.creatorSilva, João Santana da
dc.creatorJelicks, Linda A.
dc.creatorTanowitz, Herbert B.
dc.creatorRossi, Marcos Antonio
dc.date.accessioned2025-02-10T13:26:45Z
dc.date.available2025-02-10T13:26:45Z
dc.date.issued2012
dc.description.abstractChronic Chagas cardiomyopathy evolves over a long period of time after initial infection by Trypanosoma cruzi. Similarly, a cardiomyopathy appears later in life in muscular dystrophies. This study tested the hypothesis that dystrophin levels are decreased in the early stage of T. cruzi infected mice that precedes the later development of a cardiomyopathy. CD1 mice were infected with T. cruzi (Brazil strain), killed at 30 and 100 days post infection (dpi), and the intensity of inflammation, percentage of interstitial fibrosis, and dystrophin levels evaluated. Echocardiography and magnetic resonance imaging data were evaluated from 15 to 100 dpi. At 30 dpi an intense acute myocarditis with ruptured or intact intracellular parasite nests was observed. At 100 dpi a mild chronic fibrosing myocarditis was detected without parasites in the myocardium. Dystrophin was focally reduced or completely lost in cardiomyocytes at 30 dpi, with the reduction maintained up to 100 dpi. Concurrently, ejection fraction was reduced and the right ventricle was dilated. These findings support the hypothesis that the initial parasitic infection-induced myocardial dystrophin reduction/loss, maintained over time, might be essential to the late development of a cardiomyopathy in mice. 2011 Institut Pasteur. Published by Elsevier Masson SAS. All rights reserved.
dc.identifier.citationPRADO, Cibele M. et al. Early dystrophin disruption in the pathogenesis of experimental chronic Chagas cardiomyopathy. Microbes and Infection, Paris, v. 14, n. 1, p. 59-68, 2012. DOI: 10.1016/j.micinf.2011.08.010. Disponível em: https://linkinghub.elsevier.com/retrieve/pii/S1286-4579(11)00223-1. Acesso em: 7 fev. 2025.
dc.identifier.doi10.1016/j.micinf.2011.08.010
dc.identifier.issn1286-4579
dc.identifier.issne- 1769-714X
dc.identifier.urihttp://repositorio.bc.ufg.br//handle/ri/26635
dc.language.isoeng
dc.publisher.countryFranca
dc.publisher.departmentInstituto de Patologia Tropical e Saúde Pública - IPTSP (RMG)
dc.rightsAcesso Aberto
dc.rights.urihttp://creativecommons.org/licenses/by-nc-nd/4.0/
dc.subjectChronic Chagas cardiomyopathy
dc.subjectDystrophin
dc.subjectChagas disease
dc.subjectDystrophinopathy
dc.subjectTrypanosoma cruzi
dc.titleEarly dystrophin disruption in the pathogenesis of experimental chronic Chagas cardiomyopathy
dc.typeArtigo

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