Live vaccines have different NK cells and neutrophils requirements for the development of a protective immune response against tuberculosis
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2020
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It has been shown that neutrophils drive NK cells to activate DCs while NK cells regulate
neutrophils survival. In response to mycobacteria, NK cells proliferate and produces
IFN-γ, that appears to regulate the neutrophilic inflammatory responses to both M.
tuberculosis infection and BCG vaccination. Although the role of neutrophils in the
immune response to tuberculosis is a matter of debate, neutrophils were shown to
be crucial to induce specific response against mc2
-CMX vaccine. The objective of this
study was to investigate the interplay between NK cells and neutrophils in regard to the
development of a protective immune response against M. tuberculosis. Depletion of NK
cells during vaccination did not alter the total number of neutrophils or DCs, but reduced
the number of activated DCs, thus reducing the generation of Th1 specific immune
responses and the protection conferred by mc2
-CMX and BCG vaccines. However, only
in mc2
-CMX vaccination that neutrophil depletion interfered with the NK cell numbers
and protection. In conclusion, it was shown that only when both NK and neutrophils
were present, specific Th1 response and protection was achieved by mc2
-CMX vaccine,
while neutrophils although activated upon BCG vaccination were not necessary for the
induced protection.
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Protection, TB vaccine, DC, NK depletion, Neutrophil depletion
Citação
JUNQUEIRA-KIPNIS, Ana Paula; TRENTINI, Monalisa Martins; MARQUES NETO, Lázaro Moreira; KIPNIS, André. Live vaccines have different NK cells and neutrophils requirements for the development of a protective immune response against tuberculosis. Frontiers in Immunology, Lausanne, v. 11, e741, 2020. DOI: 10.3389/fimmu.2020.00741. Disponível em: https://www.frontiersin.org/journals/immunology/articles/10.3389/fimmu.2020.00741/full. Acesso em: 20 ago. 2024.