Hyptis brevipes and paullinia pinnata extracts and their fractions presenting activity against Mycobacterium abscessus subsp. massiliense
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Data
2019-09
Título da Revista
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Editor
Ruy de Souza Lino Junior
Resumo
Medicinal plants are of great interest for the discovery of new biomolecules with diversified
effects. Over the last decade different outbreaks caused by Mycobacterium abscessus
subsp. massiliense have been reported, evidencing it as an important emerging pathogen
in underdeveloped countries. This study investigated the antimycobacterial activity of six
Brazilian medicinal plant extracts and their fractions. Hyptis brevipes, Tocoyena formosa,
Randia armata, Paullinia pinnata, Lafoensia pacari and Anadenanthera colubrina were
evaluated against M. a. massiliense. Total extracts from the medicinal plants H. brevipes, T.
formosa, P. pinnata and L. pacari presented a minimal bactericidal concentration of 1 mg/
mL. After fractioning, the ethanolic fractions from H. brevipes and P. pinnata presented
bactericidal activity, and the ethyl acetate fraction from H. brevipes and T. formosa presented
antimycobacterial action. The best bactericidal function of all plant fractions was the ethanolic,
which contained rutin and rosmarinic acid that were shown to have microbicidal activity.
Descrição
Palavras-chave
Mycobacterium abscessus, Medicinal plants, Brazilian medicinal plants, HPLC, Biodiversity
Citação
NEVES, Rogério Coutinho das; ANDRADE, Rayanny Gomes; CAROLLO, Carlos Alexandre; BOARETTO, Amanda Galdi; KIPNIS, Andre; JUNQUEIRA-KIPNIS, Ana Paula. Hyptis brevipes and paullinia pinnata extracts and their fractions presenting activity against Mycobacterium abscessus subsp. Massiliense. Revista de Patologia Tropical, Goiânia, v. 48, n. 3, p. 148-160, jul./set. 2019. Disponível em: https://www.revistas.ufg.br/iptsp/article/view/58993.