Swine and poultry pathogens: the complete genome sequences of two strains of mycoplasma hyopneumoniae and a strain of mycoplasma synoviae
Carregando...
Data
2005-08
Título da Revista
ISSN da Revista
Título de Volume
Editor
Resumo
This work reports the results of analyses of three complete mycoplasma genomes, a pathogenic (7448) and
a nonpathogenic (J) strain of the swine pathogen Mycoplasma hyopneumoniae and a strain of the avian
pathogen Mycoplasma synoviae; the genome sizes of the three strains were 920,079 bp, 897,405 bp, and 799,476
bp, respectively. These genomes were compared with other sequenced mycoplasma genomes reported in the
literature to examine several aspects of mycoplasma evolution. Strain-specific regions, including integrative
and conjugal elements, and genome rearrangements and alterations in adhesin sequences were observed in the
M. hyopneumoniae strains, and all of these were potentially related to pathogenicity. Genomic comparisons revealed that reduction in genome size implied loss of redundant metabolic pathways, with maintenance of
alternative routes in different species. Horizontal gene transfer was consistently observed between M. synoviae
and Mycoplasma gallisepticum. Our analyses indicated a likely transfer event of hemagglutinin-coding DNA
sequences from M. gallisepticum to M. synoviae.
Descrição
Palavras-chave
Citação
VASCONCELOS, Ana Tereza R. et al. Swine and poultry pathogens: the complete genome sequences of two strains of mycoplasma hyopneumoniae and a strain of mycoplasma synoviae. Journal of Bacteriology, Washington, v. 187, n. 16, p. 5568-5577, Aug. 2005.