Candida albicans isoladas da cavidade bucal de crianças com síndrome de Down: ocorrência e inibição do crescimento por Streptomyces sp

Resumo

Comparison of the presence of Candida yeasts in the buccal cavity of children without and with Down’s syndrome showed a statistically significant difference in the case of children that were affected by this chromosomopathy, rendering them more predisposed to buccal candidiasis, probably due to anatomicophysiologic alterations of the mouth resulting from trisomy of chromosome 21. Constant recurrence of buccal candidiasis in children with this chromosomal alteration lead to the search for a possible therapeutic alternative. Seeking to determine the antifungal activity of Streptomyces sp isolated from various Brazilian soils, 5 strains have been tested for Candida albicans isolated from the buccal cavity of children with Down’s syndrome. It was observed that the isolate presented a diversity in the size of the halos (9-31mm in diameter) of growth inhibition of the yeasts, suggesting a possible use as a therapeutic antifungal.

Descrição

Palavras-chave

Candida albicans, Síndrome de Down, Streptomyces sp, Down’s syndrome

Citação

VIEIRA, José Daniel Gonçalves; RIBEIRO, Evandro Leão; CAMPOS, Cerise de Castro; PIMENTA, Fabiana Cristina; TOLEDO, Orlando Ayrton de; NAGATO, Gustavo Morais; SOUZA, Niwmar Alves de; FERREIRA, Wesley Magno; CARDOSO, Cléver Gomes; DIAS, Sueli Meira da Silva; ARAÚJO JÚNIOR, César Aparício de; ZATTA, Daniel Teles; SANTOS, Juliana de Sousa dos. Candida albicans isoladas da cavidade bucal de crianças com síndrome de Down: ocorrência e inibição de crescimento por Streptomyces sp. Revista da Sociedade Brasileira de Medicina Tropical, Uberaba, v. 38, n. 5, p. 383-386, set./out. 2005.