Human papillomavirus (HPV) genotype distribution in penile carcinoma: association with clinic pathological factors
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2018
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Background
Penile carcinoma (PC) is a rare, highly mutilating disease, common in developing countries.
The evolution of penile cancer includes at least two independent carcinogenic pathways,
related or unrelated to HPV infection.
Objectives
To estimate the prevalence, identify HPV genotypes, and correlate with clinicopathological
data on penile cancer.
Methods
A retrospective cohort study involving 183 patients with PC undergoing treatment in a refer ral hospital in Goiaˆnia, Goia´s, in Midwestern Brazil, from 2003 to 2015. Samples containing
paraffin embedded tumor fragments were subjected to detection and genotyping by INNO LiPA HPV. The clinicopathological variables were subjected to analysis with respect to HPV
positivity and used prevalence ratio (PR), adjusted prevalence ratio (PRa) and 95% confi dence interval (CI) as statistical measures.
Results
The prevalence of HPV DNA in PC was 30.6% (95% CI: 24.4 to 37.6), high-risk HPV 24.9%
(95% CI: 18.9 to 31.3), and 62.5% were HPV 16. There was a statistical association
between the endpoints HPV infection and HPV high risk, and the variable tumor grade II-III (p = 0.025) (p = 0.040), respectively. There was no statistical difference in disease specific
survival at 10 years between the HPV positive and negative patients (p = 0.143), and high
and low risk HPV (p = 0.325).
Conclusions
The prevalence of HPV infection was 30.6%, and 80.3% of the genotypes were identified as
preventable by anti-HPV quadrivalent or nonavalent vaccine. HPV infections and high-risk
HPV were not associated with penile carcinoma prognosis in this study.
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ARAÚJO, Lyriane Apolinário de et al. Human papillomavirus (HPV) genotype distribution in penile carcinoma: association with clinic pathological factors. Plos One, San Francisco, v. 13, n. 6, e0199557, 2018. DOI: 10.1371/journal.pone.0199557. Disponível em: https://pmc.ncbi.nlm.nih.gov/articles/PMC6021089/. Acesso em: 7 mar. 2025.