Bioatividade de Stryphnodendron adstringens, S. polyphyllum, Caryocar brasiliensis, plantas do cerrado brasileiro, sobre Trypanosoma cruzi "in vivo"

Abstract

The present work verified the action of the crude extract of the Stryphnodendron adstringens, S. polyphyllum and of the Caryocar brasiliense barks, on the parasitemia of mice inoculated with cepa Y of Trypanosoma cruzi in the acute phase of the infection, evaluating its interference on the agudization or inhibition of the infectious process. Mice (Balb/C) had been infected by intraperitoneal route with 1x10 4 tripomastigotes forms, after 24 hours inoculated by intragastric route with daily doses of 400μg/ml extracts for ten days. The evaluation of the parasitemia was achieved in intervals of 2 days until the death of the animals. During the study, it was observed that the extracts of S. adstringens and S. polyphyllum had presented a higher trypanomicidal activity after the 6 th and 8 th days, occurring a higher growth inhibition in the 8 th day, when it was compared to the control group. The crude extract of C. brasiliense presented a trypanocidal activity with growth inhibition only in the 8 th day. The results demonstrated that the extracts of the tested plants presented a significant interference on the parasitemia growth of T. cruzi, reducing the number of parasites in the mice blood.