Antimicrobial and antibiofilm effects of peptides from venom of social wasp and scorpion on multidrug-resistant Acinetobacter baumannii
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Data
2019
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Resumo
Intravascular stent infection is a rare complication with a high morbidity and high mortality;
bacteria from the hospital environment form biofilms and are often multidrug-resistant (MDR).
Antimicrobial peptides (AMPs) have been considered as alternatives to bacterial infection treatment.
We analyzed the formation of the bacterial biofilm on the vascular stents and also tested the inhibition
of this biofilm by AMPs to be used as treatment or coating. Antimicrobial activity and antibiofilm
were tested with wasp (Agelaia-MPI, Polybia-MPII, Polydim-I) and scorpion (Con10 and NDBP5.8)
AMPs against Acinetobacter baumannii clinical strains. A. baumannii formed a biofilm on the vascular
stent. Agelaia-MPI and Polybia-MPII inhibited biofilm formation with bacterial cell wall degradation.
Coating biofilms with polyethylene glycol (PEG 400) and Agelaia-MPI reduced 90% of A. baumannii
adhesion on stents. The wasp AMPs Agelaia-MPI and Polybia-MPII had better action against MDR
A. baumannii adherence and biofilm formation on vascular stents, preventing its formation and
treating mature biofilm when compared to the other tested peptides.
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AMP, Mastoparan, Acinetobacter baumannii, Stent
Citação
NEVES, Rogério Coutinho das et al. Antimicrobial and antibiofilm effects of peptides from venom of social wasp and scorpion on multidrug-resistant Acinetobacter baumannii. Toxins, Basel, v. 11, n. 4, e216, 2019. DOI: 10.3390/toxins11040216. Disponível em: https://pubmed.ncbi.nlm.nih.gov/30974767/. Acesso em: 20 ago. 2024.