IL-22 promotes ifn-γ-mediated immunity against histoplasma capsulatum infection
Nenhuma Miniatura disponível
Data
2020
Título da Revista
ISSN da Revista
Título de Volume
Editor
Resumo
Histoplasma capsulatum is the agent of histoplasmosis, one of the most frequent mycoses
in the world. The infection initiates with fungal spore inhalation, transformation into yeasts in the
lungs and establishment of a granulomatous disease, which is characterized by a Th1 response.
The production of Th1 signature cytokines, such as IFN-γ, is crucial for yeast clearance from the
lungs, and to prevent dissemination. Recently, it was demonstrated that IL-17, a Th17 signature
cytokine, is also important for fungal control, particularly in the absence of Th1 response. IL-22 is
another cytokine with multiple functions on host response and disease progression. However, little is
known about the role of IL-22 during histoplasmosis. In this study, we demonstrated that absence
of IL-22 affected the clearance of yeasts from the lungs and increased the spreading to the spleen.
In addition, IL-22 deficient mice (Il22−/−) succumbed to infection, which correlated with reductions in
the numbers of CD4+ IFN-γ+ T cells, reduced IFN-γ levels, and diminished nitric oxide synthase type
2 (NOS2) expression in the lungs. Importantly, treatment with rIFN-γ mitigated the susceptibility
of Il22−/− mice to H. capsulatum infection. These data indicate that IL-22 is crucial for IFN-γ/NO
production and resistance to experimental histoplasmosis.
Descrição
Palavras-chave
Hyperglycemia, Inflammation, Nitric oxide, Pancreas, Scorpion venom
Citação
PRADO, Morgana K. B. et al. IL-22 promotes ifn-γ-mediated immunity against histoplasma capsulatum infection. Biomolecules, Basel, v. 10, n. 6, e865, 2020. DOI: 10.3390/biom10060865. Disponível em: https://pubmed.ncbi.nlm.nih.gov/32517114/. Acesso em: 29 jan. 2025.