Doenças extra gástricas associadas à infecção por Helicobacter pylori: uma revisão integrativa
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Data
2021
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Resumo
Helicobacter pylori is a Gram-negative, microaerophilic, mobile, non-spore-forming
bacterium capable of colonizing the gastric mucosa of humans. Infection by this
microorganism causes gastric and extra gastric changes due to the chronic inflammatory
process that can promote a systemic effect and cause disruption of the homeostasis of
various organs and tissues, triggering various pathologies. The objective of this work was
to carry out a bibliographic survey of non-gastric pathologies that are triggered by chronic
infection by H. pylori, considering the pathophysiology and systemic effects on the host.
For this, an integrative literature review, with a qualitative characteristic, was carried out
in the Scientific Electronic Library Online (SCIELO), Academic Google, LilACS and
NCBI PubMed databases. Articles published in Portuguese, Spanish and English from
2010 to 2020 that addressed the topic were included and the exclusion criteria were theses,
monographs and dissertations, and articles that did not address the topic. Some groups of
non-gastric diseases associated with H. pylori infection have been identified, including
hematologic, neurological, hepatobiliary, respiratory, vascular, allergic, neoplastic,
metabolic, ocular, oral, and autoimmune diseases. The systemic effect of H. pylori
infection, where several cytokines and chemical mediars are released, causes changes and
homeostatic imbalances in different tissues and extra gastric organs of the body, and often
an exacerbated immune response occurs. Despite not being a consensus among the studies
researched, it was found that H. pylori infection may be associated with the emergence
and progression of these different pathologies.
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Helicobacter pylori, Doenças extra gástricas e desencadadas, Helicobacter pylori, Extra gastric and unchained diseases
Citação
MONTALVAO, Kariny Brito et al. Doenças extra gástricas associadas à infecção por Helicobacter pylori: uma revisão integrativa. Brazilian Journal of Health Review, Curitiba, v. 4, n. 5, p. 18734-18757, 2021. DOI: 10.34119/bjhrv4n5-023. Disponível em: https://ojs.brazilianjournals.com.br/ojs/index.php/BJHR/issue/view/145. Acesso em: 6 fev. 2025.