Resistência antimicrobiana associada em isolados clínicos de Enterococcus spp
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2011-06
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Resumo
Introduction: The increasing prevalence of enterococci strains in hospitals, particularly among
isolates of vancomycin-resistant enterococci (VRE), poses important problems because of
the limited effect of antimicrobial therapy for enterococcal infections. Methods: This work
presents a retrospective investigation of quantitative in vitro susceptibility data for the range of
antimicrobials against Enterococcus spp. isolates and evaluation of the association of resistance
between antimicrobial agents recommended as the treatment of choice for infections caused
by VRE through calculation of the relative risk. Results: Of the 156 enterococci isolates, 40
(25.6%) were resistant to 3 or more antimicrobials, including 7.7% (n = 12/156) vancomycin
resistant. The association of elevated resistance was more pronounced among VRE isolates
against alternative and primary antimicrobials for the treatment of infections caused by these
pathogens, including ampicillin (100%, RR = 7.2), streptomycin (90.9%, RR = 4.9), rifampin
(91.7%, RR = 3.1) and linezolid (50%, RR = 11.5), despite high susceptibility to this drug
(94.9%). Conclusions: The significant associated resistance to alternative and first choice
antimicrobials used in the treatment of serious infections of strains with the VRE phenotype
and that require a combined therapeutic regime, revealed even more limited therapeutic
alternatives in the institution analyzed.
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Enterococcus spp, Resistência à vancomicina, Resistência antimicrobiana associada, Enterococcus spp, Vancomycin resistance, Associated antimicrobial resistance
Citação
KOBAYASHI, Cláudia Castelo Branco Artiaga; SADOYAMA, Geraldo; VIEIRA, José Daniel Gonçalves; PIMENTA, Fabiana Cristina. Resistência antimicrobiana associada em isolados clínicos de Enterococcus spp. Revista da Sociedade Brasileira de Medicina Tropical , Uberaba, v. 44, n. 3, p. 344-348, maio/jun. 2011.