The efficacy of photobiomodulation therapy in improving tissue resilience and healing of radiation skin damage
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2022
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The increased precision, efficacy, and safety of radiation brachytherapy has tremendously
improved its popularity in cancer care. However, an unfortunate side effect of this therapy involves
localized skin damage and breakdown that are managed palliatively currently. This study was
motivated by prior reports on the efficacy of photobiomodulation (PBM) therapy in improving tissue
resilience and wound healing. We evaluated the efficacy of PBM therapy on 36 athymic mice with 125I
seed (0.42 mCi) implantation over 60 days. PBM treatments were performed with either red (660 nm)
or near-infrared (880 nm, NIR) LEDs irradiance of 40 mW/cm2
, continuous wave, fluence of 20 J/cm2
once per week. Animals were evaluated every 7 days with digital imaging, laser Doppler flowmetry,
thermal imaging, µPET-CT imaging using 18F-FDG, and histology. We observed that both PBM
treatments—red and NIR—demonstrated significantly less incidence and severity and improved
healing with skin radionecrosis. Radiation exposed tissues had improved functional parameters such
as vascular perfusion, reduced inflammation, and metabolic derangement following PBM therapy.
Histological analysis confirmed these observations with minimal damage and resolution in tissues
exposed to radiation. To our knowledge, this is the first report on the successful use of PBM therapy
for brachytherapy. The results from this study support future mechanistic lab studies and controlled
human clinical studies to utilize this innovative therapy in managing side effects from radiation
cancer treatments.
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Photobiomodulation therapy, Brachytherapy, Radiation wounds, LED, µPET-CT
Citação
MOSCA, Rodrigo Crespo et al. The efficacy of photobiomodulation therapy in improving tissue resilience and healing of radiation skin damage. Photonics, Basel, v. 9, n. 1, e10, 2022. DOI: 10.3390/photonics9010010. Disponível em: https://www.mdpi.com/2304-6732/9/1/10. Acesso em: 21 jan. 2025.