ACE2 down-regulation may act as a transient molecular disease causing RAAS dysregulation and tissue damage in the microcirculatory environment among COVID-19 patients
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2021
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Severe acute respiratory syndrome coronavirus 2, the etiologic agent of coronavirus disease 2019
(COVID-19) and the cause of the current pandemic, produces multiform manifestations throughout the
body, causing indiscriminate damage to multiple organ systems, particularly the lungs, heart, brain,
kidney, and vasculature. The aim of this review is to provide a new assessment of the data already
available for COVID-19, exploring it as a transient molecular disease that causes negative regulation of
angiotensin-converting enzyme 2, and consequently, deregulates the renin-angiotensin-aldosterone
system, promoting important changes in the microcirculatory environment. Another goal of the article
is to show how these microcirculatory changes may be responsible for the wide variety of injury
mechanisms observed in different organs in this disease. The new concept of COVID-19 provides a
unifying pathophysiological picture of this infection and offers fresh insights for a rational treatment
strategy to combat this ongoing pandemic.
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RAMOS, Simone Gusmão et al. ACE2 down-regulation may act as a transient molecular disease causing RAAS dysregulation and tissue damage in the microcirculatory environment among COVID-19 patients. American Journal of Pathology, New York, v. 191, p. 1154-1164, 2021. DOI: 10.1016/j.ajpath.2021.04.010. Disponível em: https://www.sciencedirect.com/science/article/pii/S0002944021001942?via%3Dihub. Acesso em: 5 fev. 2025.