The role of neutrophils in the induction of specific Th1 and Th17 during vaccination against tuberculosis
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2016
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Mycobacterium tuberculosis causes tuberculosis (TB), a disease that killed more than
1.5 million people worldwide in 2014, and the Bacillus Calmette Guérin (BCG) vaccine is
the only currently available vaccine against TB. However, it does not protect adults.
Th1 and Th17 cells are crucial for TB control, as well as the neutrophils that are
directly involved in DC trafficking to the draining lymph nodes and the activation of
T lymphocytes during infection. Although several studies have shown the importance
of neutrophils during M. tuberculosis infection, none have shown its role in the
development of a specific response to a vaccine. The vaccine mc2
-CMX was shown
to protect mice against M. tuberculosis challenge, mainly due to specific Th1 and Th17
cells. This study evaluated the importance of neutrophils in the generation of the Th1-
and Th17-specific responses elicited by this vaccine. The vaccine injection induced a
neutrophil rich lesion with a necrotic central area. The IL-17 KO mice did not generate
vaccine-specific Th1 cells. The vaccinated IL-22 KO mice exhibited Th1- and Th17-
specific responses. Neutrophil depletion during vaccination abrogated the induction
of Th1-specific responses and prohibited the bacterial load reduction observed in the
vaccinated animals. The results show, for the first time, the role of neutrophils in the
generation of specific Th1 and Th17 cells in response to a tuberculosis vaccine.
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Tuberculosis vaccines, Th1/Th17 responses, Neutrophils
Citação
TRENTINI,Monalisa M.; OLIVEIRA, Fábio M.; KIPNIS, André; JUNQUEIRA-KIPNIS, Ana P. The role of neutrophils in the induction of specific Th1 and Th17 during vaccination against tuberculosis. Frontiers in Microbiology, Lausanne, v. 7, e898, 2016. DOI: 10.3389/fmicb.2016.00898. Disponível em: https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4901074/. Acesso em: 22 ago. 2024.