Multibacillary leprosy patients with high and persistent serum antibodies to leprosy IDRI diagnostic-1/LID-1: higher susceptibility to develop type 2 reactions

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dc.creatorMizoguti, Danielle de Freitas
dc.creatorHungria, Emerith Mayra
dc.creatorFreitas, Aline Araújo
dc.creatorOliveira, Regiane Morillas
dc.creatorCardoso, Ludimila Paula Vaz
dc.creatorCosta, Mauricio Barcelos
dc.creatorSousa, Ana Lúcia Maroclo
dc.creatorDuthie, Malcolm S.
dc.creatorStefani, Mariane Martins de Araújo
dc.date.accessioned2019-01-29T10:24:49Z
dc.date.available2019-01-29T10:24:49Z
dc.date.issued2015-11
dc.description.abstractLeprosy inflammatory episodes [type 1 (T1R) and type 2 (T2R) reactions] represent the major cause of irrevers-ible nerve damage. Leprosy serology is known to be influenced by the patient’s bacterial index (BI) with higher posi-tivity in multibacillary patients (MB) and specific multidrug therapy (MDT) reduces antibody production. This study evaluated by ELISA antibody responses to leprosy Infectious Disease Research Institute diagnostic-1 (LID-1) fusion protein and phenolic glycolipid I (PGL-I) in 100 paired serum samples of 50 MB patients collected in the presence/absence of reactions and in nonreactional patients before/after MDT. Patients who presented T2R had a median BI of 3+, while MB patients with T1R and nonreactional patients had median BI of 2.5+ (p > 0.05). Anti-LID-1 and anti-PGL-I antibodies declined in patients diagnosed during T1R (p < 0.05). Anti-LID-1 levels waned in MB with T2R at diagnosis and nonreactional MB patients (p < 0.05). Higher anti-LID-1 levels were seen in patients with T2R at diagnosis (vs. patients with T1R at diagnosis, p = 0.008; vs. nonreactional patients, p = 0.020) and in patients with T2R during MDT (vs. nonreactional MB, p = 0.020). In MB patients, high and persistent anti-LID-1 antibody levels might be a useful tool for clinicians to predict which patients are more susceptible to develop leprosy T2R.pt_BR
dc.identifier.citationMIZOGUTI, Danielle de Freitas et al. Multibacillary leprosy patients with high and persistent serum antibodies to leprosy IDRI diagnostic-1/LID-1: higher susceptibility to develop type 2 reactions. Memórias do Instituto Oswaldo Cruz, Rio de Janeiro, v. 110, n. 7, p. 914-920, 2015.pt_BR
dc.identifier.doi10.1590/0074-02760150198
dc.identifier.issn0074-0276
dc.identifier.issn1678-8060
dc.identifier.urihttp://repositorio.bc.ufg.br/handle/ri/16889
dc.language.isoengpt_BR
dc.publisher.countryBrasilpt_BR
dc.publisher.departmentInstituto de Patologia Tropical e Saúde Pública - IPTSP (RG)pt_BR
dc.rightsAcesso Abertopt_BR
dc.subjectPGL-Ipt_BR
dc.subjectAntibodypt_BR
dc.subjectDiagnosispt_BR
dc.subjectLeprosy reactionspt_BR
dc.subjectLID-1pt_BR
dc.subjectSerologypt_BR
dc.titleMultibacillary leprosy patients with high and persistent serum antibodies to leprosy IDRI diagnostic-1/LID-1: higher susceptibility to develop type 2 reactionspt_BR
dc.typeArtigopt_BR

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