Demyelination in experimental intraventricular neurocysticercosis
Nenhuma Miniatura disponível
Data
2020
Título da Revista
ISSN da Revista
Título de Volume
Editor
Resumo
Neurocysticercosis (NCC) is classified as a neglected tropical disease, which affects mainly Latin America and Africa in spite of some
reports in North America and Europe. NCC represents the cause of up to 30% of the reported cases of epilepsy in endemic countries.
The NCC injuries present direct relation to the development stage, location, and number of parasites as well as to the host immune response.
This study aimed the characterization of the inflammatory response and tissue injuries by means of the analyses of the periventricular
and parenchymatous demyelination through the experimental intraventricular NCC infection. Therefore, BALB/c mice were submitted to
experimental NCC inoculation with Taenia crassiceps cysticerci. Their brains were removed at 7, 30, 60, and 90 days after the inoculation
(DAI), and analyzed after staining with hematoxylin and eosin (HE), Luxol Fast Blue, and Nissl. It was possible to observe ventriculomegaly,
inflammatory infiltration composed by polymorphonuclear and mononuclear cells, and foamy macrophages. The presence of inflammatory
cells was associated with neurodegeneration detected by the areas with demyelination observed initially in the periventricular area
and lately in the parenchyma. In conclusion, the presence of cysticerci and the consequent inflammation were able to promote initial
periventricular demyelination followed by parenchymatous demyelination as the infection progressed.
Descrição
Palavras-chave
Neurocisticercose, Desmielinização periventricular, Desmielinização parenquimal, Taenia crassiceps, Neurocysticercosis, Periventricular demyelination, Parenchymal demyelination, Taenia crassiceps
Citação
MOURA, Vania Beatriz Lopes et al. Demyelination in experimental intraventricular neurocysticercosis. Arquivos de Neuro-Psiquiatria, São Paulo, v. 78, n. 2, p. 103-111, 2020. DOI: 10.1590/0004-282X20190155. Disponível em: https://www.scielo.br/j/anp/a/8bSKsg4NpkhnLcG5hKZcPMf/?lang=en. Acesso em: 20 fev. 2025.