Comparative study of subcortical atrophy in patients with frontotemporal dementia and dementia with extrapyramidal signs

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dc.creatorCaixeta, Leonardo Ferreira
dc.creatorVieira, Renata Teles
dc.creatorPaes, Flávia
dc.creatorCarta, Mauro Giovanni
dc.creatorNardi, Antonio Egidio
dc.creatorArias-Carrión, Oscar
dc.creatorRocha, Nuno B. F.
dc.creatorBudde, Henning
dc.creatorMachado, Sérgio
dc.date.accessioned2019-01-23T14:57:02Z
dc.date.available2019-01-23T14:57:02Z
dc.date.issued2015
dc.description.abstractObjectives: To investigate the severity of subcortical atrophy in frontotemporal dementia (FTD) without ex-trapyramidal symptoms (EPS) and dementia with EPS. In addition, we aim to verify if there is correlation between demo-graphic and clinical characteristics and subcortical atrophy in the groups. Methodology: The sample was composed of 21 patients with dementia and EPS as well as 19 patients with FTD without EPS. A linear assessment was conducted in order to identify the degree of subcortical atrophy (i.e., bifrontal index - BFI) using MRI. Moreover, the Mini-Mental State Ex-amination (MMSE), Pfeffer Functional Activities Questionnaire (FAQ) and the Clinical Dementia Rating (CDR) were used to investigate clinical aspects. Results: It was verified that patients with dementia and EPS was older than the pa-tients with FTD (p=0.01). The severity of cognitive deficits was associated with BFI, as well as the dementia severity in the EPS group. Conclusion: FTD group presented mean BFI scores above the cutoff for normal elderly population, indi-cating the presence of subcortical atrophy in this group. Mean BFI was higher (although not statistically significant) in FTD group than in dementia with EPS, which can suggest at least that subcortical pathology in FTD may be as important as in the dementia with EPS group. Subcortical atrophy is a good biological marker for cognitive deterioration in FTD and in dementia with EPS.pt_BR
dc.identifier.citationCAIXETA, Leonardo et al. Comparative study of subcortical atrophy in patients with frontotemporal dementia and dementia with extrapyramidal signs. Clinical Practice and Epidemiology in Mental Health, Londres, v. 11, p. 125-129, 2015.pt_BR
dc.identifier.doi10.2174/1745017901511010125
dc.identifier.issn1745-0179
dc.identifier.urihttp://repositorio.bc.ufg.br/handle/ri/16818
dc.language.isoengpt_BR
dc.publisher.countryGra-bretanhapt_BR
dc.publisher.departmentInstituto de Patologia Tropical e Saúde Pública - IPTSP (RG)pt_BR
dc.rightsAcesso Abertopt_BR
dc.subjectSubcortical atrophypt_BR
dc.subjectBifrontal indexpt_BR
dc.subjectExtrapyramidal signspt_BR
dc.subjectFrontotemporal dementiapt_BR
dc.subjectStructural neuroimagingpt_BR
dc.titleComparative study of subcortical atrophy in patients with frontotemporal dementia and dementia with extrapyramidal signspt_BR
dc.typeArtigopt_BR

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