Therapeutic targets in Paracoccidioides brasiliensis: post-transcriptome perspectives
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Data
2005
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Resumo
The rise in antifungal resistance, observed as a result of
the increasing numbers of immunocompromised patients, has made the
discovery of new targets for drug therapy imperative. The description of
the Paracoccidioides brasiliensis transcriptome has allowed us to find
alternatives to refine current therapy against paracoccidioidomycosis.
We used comparative analysis of expressed sequence tags to find prom-
ising drug targets that have been addressed in other pathogens. We di-
vided the analysis into six different categories, based on the involvement
of the targeted mechanisms in the cell: i) cell wall construction, ii) plasma
membrane composition, iii) cellular machinery, iv) cellular metabolism,
v) signaling pathways, and vi) other essential processes. Through this
approach, it has been possible to infer strategies to develop alternative
drugs against this pathogen.
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Drug targets, Paracoccidioides brasiliensis, Fungi
Citação
AMARAL, André Corrêa; FERNANDES, Larissa; GALDINO, Alexsandro Sobreira; FELIPE, Maria Sueli Soares; SOARES, Célia Maria de Almeida; PEREIRA, Maristela. Therapeutic targets in Paracoccidioides brasiliensis: post-transcriptome perspectives. Genetics and Molecular Research, Ribeirão Preto, v. 4, n. 2, p. 430-449, 2005.