Topical application of melatonin accelerates the maturation of skin wounds and increases collagen deposition in a rat model of diabetes

Souza, Tainara Ribeiro de; Rocha, Viviane Lopes; Rincon, Gabriel de Castro Nunes; Oliveira Junior, Edilson Ribeiro de; Celes, Mara Rúbia Nunes; Lima, Eliana Martins; Amaral, Andre Correa; Miguel, Marina Pacheco; Menezes, Liliana Borges de

Topical application of melatonin accelerates the maturation of skin wounds and increases collagen deposition in a rat model of diabetes

Data

2022

Autores

Souza, Tainara Ribeiro de

Rocha, Viviane Lopes

Rincon, Gabriel de Castro Nunes

Oliveira Junior, Edilson Ribeiro de

Celes, Mara Rúbia Nunes

Lima, Eliana Martins

Amaral, Andre Correa

Miguel, Marina Pacheco

Menezes, Liliana Borges de

Resumo

Aims This study aimed to evaluate the cicatricial potential of melatonin when applied to wounds of diabetic rats. Matherials and methods The formulation containing melatonin was developed and applied topically to cutaneous wounds of diabetic rats. 48 Wistar rats were used, divided into two groups of 24 diabetic animals each: (i) control group (CG), the animals received topical application of the no-melatonin formulation; (ii) treatment group (TG), the animals received topical application of the melatonin-containing formulation. All animals in each group were treated at four time points: 3, 7, 14, and 21 days. Each subgroup consisted of six animals. Results The treatment with melatonin improved wound healing by promoting wound closure earlier than the control group evaluated. Also improved a better resolution of the inflammatory phase observed mainly at 7 days, higher tissue maturation and expressive collagen deposition. Conclusion The observed data reveal that the use of melatonin topically could be a promising strategy for the healing of wounds in diabetes. The results of this study elucidate the effects of previously described pathways in which it is proposed that melatonin acts promoting wound healing in diabetes.

Palavras-chave

Inflammation, Chronic wounds, Diabetes mellitus, Topical application, Healing

Citação

SOUZA, Tainara Ribeiro de et al. Topical application of melatonin accelerates the maturation of skin wounds and increases collagen deposition in a rat model of diabetes. Journal of Tissue Viability, Salisbury, v. 31, n. 4, p. 606-613, 2022. DOI: 10.1016/j.jtv.2022.07.015. Disponível em: https://www.sciencedirect.com/science/article/pii/S0965206X22000912?via%3Dihub. Acesso em: 5 fev. 2025.