Galectin-3 orchestrates the histology of mesentery and protects liver during lupus-like syndrome induced by pristane
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2019
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Galectin-3 (Gal-3) controls intercellular and cell-extracellular matrix interactions during immunological
responses. In chronic infammation, Gal-3 is associated with fbrotic events, regulates B cell
diferentiation and delays lupus progression. Gal-3 defcient mice (Lgals3−/−) have intense germinal
center formation and atypical plasma cell generation correlated to high levels IgG, IgE, and IgA. Here,
we used pristane (2,6,10,14-tetramethylpentadecane) to induce lupus-like syndrome in Lgals3−/− and
Lgals3+/+ BALB/c mice. Mesentery and peritoneal cells were monitored because promptly react to
pristane injected in the peritoneal cavity. For the frst time, mesenteric tissues have been associated to
the pathogenesis of experimental lupus-like syndrome. In Lgals3+/+ pristane-induced mice, mesentery
was hallmarked by intense fbrogranulomatous reaction restricted to submesothelial regions and
organized niches containing macrophages and B lymphocytes and plasma cells. In contrast, Lgals3−/−
pristane-treated mice had difuse mesenteric fbrosis afecting submesothelium and peripheral tissues,
atypical M1/M2 macrophage polarization and signifcant DLL1+ cells expansion, suggesting possible
involvement of Notch/Delta pathways in the disease. Early infammatory reaction to pristane was
characterized by signifcant disturbances on monocyte recruitment, macrophage diferentiation and
dendritic cell (DC) responses in the peritoneal cavity of pristane-induced Lgals3−/− mice. A correlative
analysis showed that mesenteric damages in the absence of Gal-3 were directly associated with severe
portal infammation and hepatitis. In conclusion, it has suggested that Gal-3 orchestrates histological
organization in the mesentery and prevents lupoid hepatitis in experimental lupus-like syndrome by
controlling macrophage polarization, Notch signaling pathways and DC diferentiation in mesenteric
structures.
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LEMOS, F. S. et al. Galectin-3 orchestrates the histology of mesentery and protects liver during lupus-like syndrome induced by pristane. Scientific Reports, London, v. 9, e14620, 2019. DOI: 10.1038/s41598-019-50564-8. Disponível em: https://www.nature.com/articles/s41598-019-50564-8. Acesso em: 21 jan. 2025.