Activity of low level laser therapy on burning wounds in diabetic rats
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2016
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OBJECTIVE: This study evaluated the effects of low level laser (LLL) therapy in the healing of third degree burning wounds in diabetic and non-diabetic Wistar rats.
METHODS: The diabetes was experimentally induced with streptozotocine 14 days before the burning injury induction. The rats suffered the induction of third-degree burning injury and were divided into four groups as follows: control group; non-diabetic treated group; diabetic group; diabetic treated group. All animals received occlusive bandages during the experimental days. The treated animals received the following treatment in alternate days: diode GaAlAs laser (650 nm/ 12 mW), fluency of 3 J/cm2 until the 7th experimental day followed by 6 J/cm2 from the 7th day until the euthanasia day. The burning wounds were morphometrically, macroscopically and microscopically evaluated at 3, 7, 14, 21 and 30 days after the induction.
RESULTS: The wound contraction was significantly higher in all experimental days in treated groups when compared to the diabetic and non-diabetic control groups. Microscopically, there was a significant increase in angiogenesis and in fibrogenesis during the proliferative stage in the treated groups.
CONCLUSION: Therefore, we conclude that LLL therapy favored the tissue healing process with 3 J/cm2 dosage for the inflammatory stage and with 6 J/cm2 dosage for the proliferative and remodeling ones, accelerating the burning wound contraction and improving the healing process.
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Burns, Diabetes mellitus, Low-level light therapy, Pathology, Queimaduras, Diabetes mellitus, Terapia com luz de baixa intensidade, Patologia
Citação
FANTINATI, Marcelo S. et al. Activity of low level laser therapy on burning wounds in diabetic rats. Revista Brasileira de Queimaduras, Goiânia, v. 15, n. 1, p. 42-49, 2016. Disponível em: http://www.rbqueimaduras.com.br/details/291/en-US/atividade-terapeutica-do-laser-de-baixa-intensidade-em-queimaduras-em-ratos-diabeticos. Acesso em: 24 fev. 2025.