Oral nitazoxanide treatment of experimental neurocysticercosis induces gluconeogenesis in Taenia crassiceps cysticerci

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dc.creatorLima, Nayana Ferreira de
dc.creatorPicanço, Guaraciara de Andrade
dc.creatorAlves, Daniella de Sousa Mendes Moreira
dc.creatorSilva, Luciana Damacena
dc.creatorIsac, Eliana
dc.creatorCosta, Tatiane Luiza da
dc.creatorLino Junior, Ruy de Souza
dc.creatorVinaud, Marina Claire
dc.date.accessioned2025-02-27T13:01:36Z
dc.date.available2025-02-27T13:01:36Z
dc.date.issued2019
dc.description.abstractNeurocysticercosis is the most frequent helminthiasis of the central nervous system and is caused by the presence of Taenia solium cysticerci. Nitazoxanide (NTZ) is an antifolate containing the pyrrolopyrimidine-based nucleus that exerts its antiprotozoal activity due to interference with the pyruvate:ferredoxin oxidoreductase (PFOR) enzyme which is essential to anaerobic energy metabolism. The aim of this work was to determine the effect of NTZ on the energetic metabolism of Taenia crassiceps cysticerci intracranially inoculated BALB /c mice. The infected animals were treated with a single oral dose of NTZ 30 days after the inoculation. Analysis of the organic acids was performed through high performance liquid chromatography. Glucose was detected only in the treated groups, alongside with a significant decrease in lactate, pyruvate and oxaloacetate concentrations which indicate an increase in gluconeogenesis. The non-detection of alpha-ketoglutarate indicated the use of the fumarate reductase pathway in all groups. It was possible to confirm the drugs mode of action due to the non-detection of acetate in the treated groups. There was an increase in the fatty acids oxidation. Therefore it was possible to observe that NTZ induces gluconeogenesis as well as the increase of alternative energetic pathways such as fatty acids oxidation in T. crassiceps cysticerci.
dc.identifier.citationLIMA, Nayana F. et al. Oral nitazoxanide treatment of experimental neurocysticercosis induces gluconeogenesis in Taenia crassiceps cysticerci. Acta Tropica, Amsterdam, v. 190, p. 361-364, 2019. DOI: 10.1016/j.actatropica.2018.12.017. Disponível em: https://www.sciencedirect.com/science/article/pii/S0001706X18305680?via%3Dihub. Acesso em: 21 fev. 2025.
dc.identifier.doi10.1016/j.actatropica.2018.12.017
dc.identifier.issn0001-706X
dc.identifier.issne- 1873-6254
dc.identifier.urihttps://www.sciencedirect.com/science/article/pii/S0001706X18305680?via%3Dihub
dc.language.isoeng
dc.publisher.departmentInstituto de Patologia Tropical e Saúde Pública - IPTSP (RMG)
dc.rightsAcesso Restrito
dc.subjectMetabolism
dc.subjectExperimental neurocysticercosis
dc.subjectNitazoxanide
dc.subjectTaenia crassiceps
dc.subjectFatty acids oxidation
dc.titleOral nitazoxanide treatment of experimental neurocysticercosis induces gluconeogenesis in Taenia crassiceps cysticerci
dc.typeArtigo

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