Identification and biological characterization of Leishmania (Viannia) guyanensis isolated from a patient with tegumentary leishmaniasis in Goiás, a nonendemic area for this species in Brazil

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dc.creatorPires, Alause da Silva
dc.creatorBorges, Arissa Felipe
dc.creatorCoelho, Adriano Cappellazzo
dc.creatorDorta, Miriam Cristina Leandro
dc.creatorLino Junior, Ruy de Souza
dc.creatorPereira, Ledice Inacia de Araújo
dc.creatorPinto, Sebastião Alves
dc.creatorOliveira, Milton Adriano Pelli de
dc.creatorMatos, Grazzielle Guimarães de
dc.creatorAbrahamsohn, Ises de Almeida
dc.creatorUliana, Silvia Reni Bortolin
dc.creatorLima, Glória Maria Collet de Araújo
dc.creatorDias, Fátima Ribeiro
dc.date.accessioned2018-07-20T10:26:37Z
dc.date.available2018-07-20T10:26:37Z
dc.date.issued2015
dc.description.abstractThe aim of this study was to characterize clinical field isolates of Leishmania spp. obtained from patients with American Tegumentary Leishmaniasis (ATL) who live in Goiás state, Brazil. The presumed areas of infection were in Goiás, Tocantins, and Pará states. Three isolates of parasites were identified as L. (Viannia) braziliensis and one as L. (V.) guyanensis. The in vitro growth profiles were found to be similar for all parasites. Nevertheless, in C57BL/6 mice, L. (V.) guyanensis infection was better controlled than L. (V.) braziliensis. Yet in C57BL/6 mice deficient in interferon gamma, L. (V.) guyanensis lesions developed faster than those caused by L. (V.) braziliensis isolates. In BALB/c mice, the development of lesions was similar for isolates from both species; however, on the 11th week of infection, amastigotes could not be observed in macrophages from L. (V.) guyanensis-infected mice. Thus, L. (V.) guyanensis can be circulating in Goiás, a state where autochthonous cases of this species had not yet been reported. Considering the difficulties to differentiate L. (V.) guyanensis from L. (V.) braziliensis at the molecular, morphological, and clinical (human and murine models) levels, the presence of L. (V.) guyanensis infections is possibly underestimated in several regions of Brazil.pt_BR
dc.identifier.citationPIRES, Alause da Silva; BORGES, Arissa Felipe;COELHO, Adriano Cappellazzo; DORTA, Miriam Leandro; LINO JÚNIOR, Ruy de Sousa; PEREIRA, Ledice Inácia de Araújo; PINTO, Sebastião Alves; OLIVEIRA, Milton Adriano Pelli de; MATOS, Grazzielle Guimarães de; ABRAHAMSOHN, Ises A.; ULIANA, Silvia Reni B.; LIMA, Glória Maria Collet de Araújo; RIBEIRO-DIAS, Fátima. Identification and Biological Characterization of Leishmania (Viannia) guyanensis Isolated from a Patient with Tegumentary Leishmaniasis in Goiás, a Nonendemic Area for This Species in Brazil. BioMed Research International, London, v. 2015, p. 1-11, 2015.pt_BR
dc.identifier.doi10.1155/2015/350764
dc.identifier.issn2314-6133
dc.identifier.issne- 2314-6141
dc.identifier.urihttp://repositorio.bc.ufg.br/handle/ri/15434
dc.language.isoengpt_BR
dc.publisher.countryGra-bretanhapt_BR
dc.publisher.departmentInstituto de Patologia Tropical e Saúde Pública - IPTSP (RG)pt_BR
dc.rightsAcesso Abertopt_BR
dc.titleIdentification and biological characterization of Leishmania (Viannia) guyanensis isolated from a patient with tegumentary leishmaniasis in Goiás, a nonendemic area for this species in Brazilpt_BR
dc.typeArtigopt_BR

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