Identification and biological characterization of Leishmania (Viannia) guyanensis isolated from a patient with tegumentary leishmaniasis in Goiás, a nonendemic area for this species in Brazil
dc.creator | Pires, Alause da Silva | |
dc.creator | Borges, Arissa Felipe | |
dc.creator | Coelho, Adriano Cappellazzo | |
dc.creator | Dorta, Miriam Cristina Leandro | |
dc.creator | Lino Junior, Ruy de Souza | |
dc.creator | Pereira, Ledice Inacia de Araújo | |
dc.creator | Pinto, Sebastião Alves | |
dc.creator | Oliveira, Milton Adriano Pelli de | |
dc.creator | Matos, Grazzielle Guimarães de | |
dc.creator | Abrahamsohn, Ises de Almeida | |
dc.creator | Uliana, Silvia Reni Bortolin | |
dc.creator | Lima, Glória Maria Collet de Araújo | |
dc.creator | Dias, Fátima Ribeiro | |
dc.date.accessioned | 2018-07-20T10:26:37Z | |
dc.date.available | 2018-07-20T10:26:37Z | |
dc.date.issued | 2015 | |
dc.description.abstract | The aim of this study was to characterize clinical field isolates of Leishmania spp. obtained from patients with American Tegumentary Leishmaniasis (ATL) who live in Goiás state, Brazil. The presumed areas of infection were in Goiás, Tocantins, and Pará states. Three isolates of parasites were identified as L. (Viannia) braziliensis and one as L. (V.) guyanensis. The in vitro growth profiles were found to be similar for all parasites. Nevertheless, in C57BL/6 mice, L. (V.) guyanensis infection was better controlled than L. (V.) braziliensis. Yet in C57BL/6 mice deficient in interferon gamma, L. (V.) guyanensis lesions developed faster than those caused by L. (V.) braziliensis isolates. In BALB/c mice, the development of lesions was similar for isolates from both species; however, on the 11th week of infection, amastigotes could not be observed in macrophages from L. (V.) guyanensis-infected mice. Thus, L. (V.) guyanensis can be circulating in Goiás, a state where autochthonous cases of this species had not yet been reported. Considering the difficulties to differentiate L. (V.) guyanensis from L. (V.) braziliensis at the molecular, morphological, and clinical (human and murine models) levels, the presence of L. (V.) guyanensis infections is possibly underestimated in several regions of Brazil. | pt_BR |
dc.identifier.citation | PIRES, Alause da Silva; BORGES, Arissa Felipe;COELHO, Adriano Cappellazzo; DORTA, Miriam Leandro; LINO JÚNIOR, Ruy de Sousa; PEREIRA, Ledice Inácia de Araújo; PINTO, Sebastião Alves; OLIVEIRA, Milton Adriano Pelli de; MATOS, Grazzielle Guimarães de; ABRAHAMSOHN, Ises A.; ULIANA, Silvia Reni B.; LIMA, Glória Maria Collet de Araújo; RIBEIRO-DIAS, Fátima. Identification and Biological Characterization of Leishmania (Viannia) guyanensis Isolated from a Patient with Tegumentary Leishmaniasis in Goiás, a Nonendemic Area for This Species in Brazil. BioMed Research International, London, v. 2015, p. 1-11, 2015. | pt_BR |
dc.identifier.doi | 10.1155/2015/350764 | |
dc.identifier.issn | 2314-6133 | |
dc.identifier.issn | e- 2314-6141 | |
dc.identifier.uri | http://repositorio.bc.ufg.br/handle/ri/15434 | |
dc.language.iso | eng | pt_BR |
dc.publisher.country | Gra-bretanha | pt_BR |
dc.publisher.department | Instituto de Patologia Tropical e Saúde Pública - IPTSP (RG) | pt_BR |
dc.rights | Acesso Aberto | pt_BR |
dc.title | Identification and biological characterization of Leishmania (Viannia) guyanensis isolated from a patient with tegumentary leishmaniasis in Goiás, a nonendemic area for this species in Brazil | pt_BR |
dc.type | Artigo | pt_BR |
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