Comparison of two rapid tests for anti-phenolic glycolipid-I serology in Brazil and Nepal

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dc.creatorStefani, Mariane Martins de Araújo
dc.creatorGrassi, Adriano Badotti
dc.creatorSampaio, Lucas Henrique
dc.creatorSousa, Ana Lúcia Osório Maroclo de
dc.creatorCosta, Maurício Barcelos
dc.creatorScheelbeek, Pauline
dc.creatorNeupane, Kapil D.
dc.creatorHagge, Deanna A.
dc.creatorMacdonald, Murdo
dc.creatorSang-Nae, Cho
dc.creatorOskam, Linda
dc.creatorBührer-Sékula, Samira
dc.date.accessioned2019-01-29T10:42:26Z
dc.date.available2019-01-29T10:42:26Z
dc.date.issued2012
dc.description.abstractThe diagnosis of leprosy continues to be based on clinical symptoms and early diagnosis and treatment are criti-cal to preventing disability and transmission. Sensitive and specific laboratory tests are not available for diagnosing leprosy. Despite the limited applicability of anti-phenolic glycolipid-I (PGL-I) serology for diagnosis, it has been suggested as an additional tool to classify leprosy patients (LPs) for treatment purposes. Two formats of rapid tests to detect anti-PGL-I antibodies [ML immunochromatography assay (ICA) and ML Flow] were compared in differ-ent groups, multibacillary patients, paucibacillary patients, household contacts and healthy controls in Brazil and Nepal. High ML Flow intra-test concordance was observed and low to moderate agreement between the results of ML ICA and ML Flow tests on the serum of LPs was observed. LPs were “seroclassified” according to the results of these tests and the seroclassification was compared to other currently used classification systems: the World Health Organization operational classification, the bacilloscopic index and the Ridley-Jopling classification. When analysing the usefulness of these tests in the operational classification of PB and MB leprosy for treatment and follow-up purposes, the ML Flow test was the best point-of-care test for subjects in Nepal and despite the need for sample dilution, the ML ICA test yielded better performance among Brazilian subjects. Our results identified pos-sible ways to improve the performance of both tests.pt_BR
dc.identifier.citationSTEFANI, Mariane Martins de Araújo et al. Comparison of two rapid tests for anti phenolic glycolipid-I serology in Brazil and Nepal. Memórias do Instituto Oswaldo Cruz, Rio de Janeiro, v. 107, suppl. 1, p. 124-131, 2012.pt_BR
dc.identifier.doi10.1590/S0074-02762012000900019
dc.identifier.issn0074-0276
dc.identifier.issne- 1678-8060
dc.identifier.urihttp://repositorio.bc.ufg.br/handle/ri/16895
dc.language.isoengpt_BR
dc.publisher.countryBrasilpt_BR
dc.publisher.departmentInstituto de Patologia Tropical e Saúde Pública - IPTSP (RG)pt_BR
dc.rightsAcesso Abertopt_BR
dc.subjectImmunochromatographypt_BR
dc.subjectLeprosypt_BR
dc.subjectSerologic testspt_BR
dc.titleComparison of two rapid tests for anti-phenolic glycolipid-I serology in Brazil and Nepalpt_BR
dc.typeArtigopt_BR

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